Abstract
We report a copper-catalyzed enantioselective hydroboration of α,β-unsaturated aldehydes with pinacolborane. α,β-Unsaturated aldehydes were converted to the corresponding γ-pinacolboronate alcohols in good yields and enantioselectivities through consecutive hydroboration of the C=O and C=C bonds. This process provides simple access to the hydroborated product of allylic alcohols, and the resulting γ-pinacolboronate alcohols could be utilized in various transformations.
Original language | English |
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Pages (from-to) | 4429-4434 |
Number of pages | 6 |
Journal | Journal of Organic Chemistry |
Volume | 84 |
Issue number | 7 |
DOIs | |
State | Published - 5 Apr 2019 |
Bibliographical note
Funding Information:This research was supported by a National Research Foundation of Korea grant (NRF-2016R1A2B4011719), funded by the Korean government (MEST).
Publisher Copyright:
© 2019 American Chemical Society.