Asymmetric Amyloid Deposition as an Early Sign of Progression in Mild Cognitive Impairment Due to Alzheimer Disease

Hai Jeon Yoon, Bom Sahn Kim, Jee Hyang Jeong, Geon Ha Kim, Hee Kyung Park, Min Young Chun

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Purpose In typical Alzheimer disease with dementia (ADD), amyloid pathologies affect both cerebral hemispheres symmetrically. However, the spatial distribution of amyloid-ß (Aß) in the early stage of ADD or over the course of disease has not been investigated. Therefore, we explored asymmetric pattern of Aß deposition in both hemispheres according to the ADD continuum using 18F-florbetaben PET. Methods Sixty-eight subjects, including 15 Aß-negative normal controls, 28 Aß-positive mild cognitive impairment (Aß+ MCI), and 25 Aß-positive ADD (Aß+ ADD) subjects, were enrolled. Differences in the asymmetry index and SUV ratio in each of the 6 target regions (4 cortical lobes, cingulate, precuneus) plus composite region between groups were explored. Results The composite and target regional asymmetry indices were significantly different between groups and was highest in Aß+ MCI (composite, occipital, and temporal, P < 0.001; frontal, P = 0.004). The composite and target regional SUV ratios were significantly different according to 3 groups with gradual increase and were highest in Aß+ ADD (composite and all target regions, P < 0.001). Conclusions The asymmetric pattern of amyloid deposition was distinct between Aß-negative normal controls and Aß+ MCI. This pattern disappeared as the disease progressed. These data indicate that asymmetric amyloid deposition may be an early sign of MCI over the course of ADD.

Original languageEnglish
Pages (from-to)527-531
Number of pages5
JournalClinical Nuclear Medicine
Issue number7
StatePublished - 2021

Bibliographical note

Funding Information:
Conflicts of interest and sources of funding: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (grant HI18C0460). This research was supported by the Original Technology Research Program for Brain Science through the National Research Foundation of South Korea (NRF) funded by the Ministry of Science and ICT (NRF-2018M3C7A1057137) and by grants from the NRF (2018R1D1A1B07049400 and 2018R1D1A1B07045321). None declared to all authors.

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.


  • Alzheimer disease with dementia
  • F-florbetaben (FBB)
  • PET
  • amyloid deposition
  • asymmetry index
  • mild cognitive impairment


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