Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease

Chang Mo Moon; Jae Hee Cheon; Seung Won Kim; Dong Jik Shin; Eun Soo Kim; Eun Soon Shin; Yoon Kang; Jae Jun Park; Sung Pil Hong; Su Youn Nam; Tae Il Kim; Won Ho Kim

doi:10.1016/j.lfs.2010.02.016

Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease

Chang Mo Moon, Jae Hee Cheon, Seung Won Kim, Dong Jik Shin, Eun Soo Kim, Eun Soon Shin, Yoon Kang, Jae Jun Park, Sung Pil Hong, Su Youn Nam, Tae Il Kim, Won Ho Kim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Aims: The STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of many immune-mediated diseases. We investigated the relationship between STAT4 single nucleotide polymorphisms (SNPs) and susceptibility to ulcerative colitis (UC) and Crohn's disease (CD) and disease phenotypes in the Korean population. Main methods: We performed a case-control association study in individuals with UC (N=246), CD (N=182), and healthy controls (N=229). Key findings: We genotyped 8 STAT4 SNPs (rs11889341, rs7574865, rs8179673, rs6752770, rs925847, rs10168266, rs10181656, and rs11685878) in the STAT4 gene in patients and controls. SNP rs925847 in the STAT4 gene was significantly associated with susceptibility to UC (P=0.025; OR. =0.63) in dominant genotype analysis, though none of these SNPs were associated with CD susceptibility. Moreover, a significant association was identified between SNP rs11889341 and joint involvement (P=0.040; OR. =3.79), and between SNP rs925847 and eye involvement (P=0.030; OR. =2.42) in UC patients. For CD, rs925847 genetic variant was associated with joint (P=0.029; OR. =3.93) and perianal lesions (P=0.033; OR. =2.27). Significance: Our data demonstrated that the STAT4 genetic variants could predispose an individual to IBD and its extra-intestinal ailments in Koreans, suggesting the common pathogenesis of IBD (especially, extra-intestinal manifestations) and other autoimmune diseases.

Original language	English
Pages (from-to)	661-667
Number of pages	7
Journal	Life Sciences
Volume	86
Issue number	17-18
DOIs	https://doi.org/10.1016/j.lfs.2010.02.016
State	Published - Apr 2010

Bibliographical note

Funding Information:
This work was supported by a grant of the 2009 Good Health R&D Project, Ministry of Health and Welfare, Republic of Korea [grant number A084943 ]. We would like to thank the blood donors for their contribution to this study.

Keywords

Crohn's disease
Inflammatory bowel disease
Polymorphism
Signal transducer and activator of transcription 4
Ulcerative colitis

Access to Document

10.1016/j.lfs.2010.02.016

Cite this

Moon, C. M., Cheon, J. H., Kim, S. W., Shin, D. J., Kim, E. S., Shin, E. S., Kang, Y., Park, J. J., Hong, S. P., Nam, S. Y., Kim, T. I., & Kim, W. H. (2010). Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease. Life Sciences, 86(17-18), 661-667. https://doi.org/10.1016/j.lfs.2010.02.016

@article{73e974c697a34e1baa8b0d9c50a3dae5,

title = "Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease",

abstract = "Aims: The STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of many immune-mediated diseases. We investigated the relationship between STAT4 single nucleotide polymorphisms (SNPs) and susceptibility to ulcerative colitis (UC) and Crohn's disease (CD) and disease phenotypes in the Korean population. Main methods: We performed a case-control association study in individuals with UC (N=246), CD (N=182), and healthy controls (N=229). Key findings: We genotyped 8 STAT4 SNPs (rs11889341, rs7574865, rs8179673, rs6752770, rs925847, rs10168266, rs10181656, and rs11685878) in the STAT4 gene in patients and controls. SNP rs925847 in the STAT4 gene was significantly associated with susceptibility to UC (P=0.025; OR. =0.63) in dominant genotype analysis, though none of these SNPs were associated with CD susceptibility. Moreover, a significant association was identified between SNP rs11889341 and joint involvement (P=0.040; OR. =3.79), and between SNP rs925847 and eye involvement (P=0.030; OR. =2.42) in UC patients. For CD, rs925847 genetic variant was associated with joint (P=0.029; OR. =3.93) and perianal lesions (P=0.033; OR. =2.27). Significance: Our data demonstrated that the STAT4 genetic variants could predispose an individual to IBD and its extra-intestinal ailments in Koreans, suggesting the common pathogenesis of IBD (especially, extra-intestinal manifestations) and other autoimmune diseases.",

keywords = "Crohn's disease, Inflammatory bowel disease, Polymorphism, Signal transducer and activator of transcription 4, Ulcerative colitis",

author = "Moon, {Chang Mo} and Cheon, {Jae Hee} and Kim, {Seung Won} and Shin, {Dong Jik} and Kim, {Eun Soo} and Shin, {Eun Soon} and Yoon Kang and Park, {Jae Jun} and Hong, {Sung Pil} and Nam, {Su Youn} and Kim, {Tae Il} and Kim, {Won Ho}",

note = "Funding Information: This work was supported by a grant of the 2009 Good Health R&D Project, Ministry of Health and Welfare, Republic of Korea [grant number A084943 ]. We would like to thank the blood donors for their contribution to this study. ",

year = "2010",

month = apr,

doi = "10.1016/j.lfs.2010.02.016",

language = "English",

volume = "86",

pages = "661--667",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "17-18",

}

TY - JOUR

T1 - Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease

AU - Moon, Chang Mo

AU - Cheon, Jae Hee

AU - Kim, Seung Won

AU - Shin, Dong Jik

AU - Kim, Eun Soo

AU - Shin, Eun Soon

AU - Kang, Yoon

AU - Park, Jae Jun

AU - Hong, Sung Pil

AU - Nam, Su Youn

AU - Kim, Tae Il

AU - Kim, Won Ho

N1 - Funding Information: This work was supported by a grant of the 2009 Good Health R&D Project, Ministry of Health and Welfare, Republic of Korea [grant number A084943 ]. We would like to thank the blood donors for their contribution to this study.

PY - 2010/4

Y1 - 2010/4

N2 - Aims: The STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of many immune-mediated diseases. We investigated the relationship between STAT4 single nucleotide polymorphisms (SNPs) and susceptibility to ulcerative colitis (UC) and Crohn's disease (CD) and disease phenotypes in the Korean population. Main methods: We performed a case-control association study in individuals with UC (N=246), CD (N=182), and healthy controls (N=229). Key findings: We genotyped 8 STAT4 SNPs (rs11889341, rs7574865, rs8179673, rs6752770, rs925847, rs10168266, rs10181656, and rs11685878) in the STAT4 gene in patients and controls. SNP rs925847 in the STAT4 gene was significantly associated with susceptibility to UC (P=0.025; OR. =0.63) in dominant genotype analysis, though none of these SNPs were associated with CD susceptibility. Moreover, a significant association was identified between SNP rs11889341 and joint involvement (P=0.040; OR. =3.79), and between SNP rs925847 and eye involvement (P=0.030; OR. =2.42) in UC patients. For CD, rs925847 genetic variant was associated with joint (P=0.029; OR. =3.93) and perianal lesions (P=0.033; OR. =2.27). Significance: Our data demonstrated that the STAT4 genetic variants could predispose an individual to IBD and its extra-intestinal ailments in Koreans, suggesting the common pathogenesis of IBD (especially, extra-intestinal manifestations) and other autoimmune diseases.

AB - Aims: The STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of many immune-mediated diseases. We investigated the relationship between STAT4 single nucleotide polymorphisms (SNPs) and susceptibility to ulcerative colitis (UC) and Crohn's disease (CD) and disease phenotypes in the Korean population. Main methods: We performed a case-control association study in individuals with UC (N=246), CD (N=182), and healthy controls (N=229). Key findings: We genotyped 8 STAT4 SNPs (rs11889341, rs7574865, rs8179673, rs6752770, rs925847, rs10168266, rs10181656, and rs11685878) in the STAT4 gene in patients and controls. SNP rs925847 in the STAT4 gene was significantly associated with susceptibility to UC (P=0.025; OR. =0.63) in dominant genotype analysis, though none of these SNPs were associated with CD susceptibility. Moreover, a significant association was identified between SNP rs11889341 and joint involvement (P=0.040; OR. =3.79), and between SNP rs925847 and eye involvement (P=0.030; OR. =2.42) in UC patients. For CD, rs925847 genetic variant was associated with joint (P=0.029; OR. =3.93) and perianal lesions (P=0.033; OR. =2.27). Significance: Our data demonstrated that the STAT4 genetic variants could predispose an individual to IBD and its extra-intestinal ailments in Koreans, suggesting the common pathogenesis of IBD (especially, extra-intestinal manifestations) and other autoimmune diseases.

KW - Crohn's disease

KW - Inflammatory bowel disease

KW - Polymorphism

KW - Signal transducer and activator of transcription 4

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=77951224334&partnerID=8YFLogxK

U2 - 10.1016/j.lfs.2010.02.016

DO - 10.1016/j.lfs.2010.02.016

M3 - Article

C2 - 20176035

AN - SCOPUS:77951224334

SN - 0024-3205

VL - 86

SP - 661

EP - 667

JO - Life Sciences

JF - Life Sciences

IS - 17-18

ER -

Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this