TY - JOUR
T1 - Association of Plasma Carotenoid and Malondialdehyde Levels with Physical Performance in Korean Adolescents
AU - Joo, Heeyeon
AU - Hwang, Jiyoung
AU - Kim, Ji Yeon
AU - Park, Saejong
AU - Kim, Hyesook
AU - Kwon, Oran
N1 - Funding Information:
Funding: This research was funded by the Bio-Synergy Research Project of the Ministry of Science and ICT through the National Research Foundation, grant number NRF-2012M3A9C4048761.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Increased oxidative stress has been shown to lead to muscle damage and reduced physical performance. The antioxidant mechanism is most likely to reduce these relationships, but in the context of the action of carotenoids, more research is needed. This study aimed to investigate whether carotenoids modify the association between plasma malondialdehyde (MDA) and physical performance in Korean adolescents. The study sample consisted of 381 adolescents (164 boys, 217 girls) aged 13–18, who participated in the 2018 National Fitness Award Project. We quantified α-carotene, β-carotene, β-cryptoxanthin, lutein, zeaxanthin, lycopene, and MDA levels in plasma using HPLC with photodiode array detection. Among boys but not girls, plasma MDA level was negatively associated (β = −0.279, p = 0.0030) with total plasma carotenoid levels and marginally negatively associated (β = −0.907, p = 0.0876) with absolute hand grip strength. After adjustment for covariates in boys, the MDA level was negatively associated with absolute hand grip strength and relative hand grip strength; this association was observed only in groups with individual carotenoid and total carotenoid values below the median. These findings support a significant association between plasma MDA level and hand grip strength, and this association has been potentially modified by plasma levels of carotenoids in Korean male adolescents.
AB - Increased oxidative stress has been shown to lead to muscle damage and reduced physical performance. The antioxidant mechanism is most likely to reduce these relationships, but in the context of the action of carotenoids, more research is needed. This study aimed to investigate whether carotenoids modify the association between plasma malondialdehyde (MDA) and physical performance in Korean adolescents. The study sample consisted of 381 adolescents (164 boys, 217 girls) aged 13–18, who participated in the 2018 National Fitness Award Project. We quantified α-carotene, β-carotene, β-cryptoxanthin, lutein, zeaxanthin, lycopene, and MDA levels in plasma using HPLC with photodiode array detection. Among boys but not girls, plasma MDA level was negatively associated (β = −0.279, p = 0.0030) with total plasma carotenoid levels and marginally negatively associated (β = −0.907, p = 0.0876) with absolute hand grip strength. After adjustment for covariates in boys, the MDA level was negatively associated with absolute hand grip strength and relative hand grip strength; this association was observed only in groups with individual carotenoid and total carotenoid values below the median. These findings support a significant association between plasma MDA level and hand grip strength, and this association has been potentially modified by plasma levels of carotenoids in Korean male adolescents.
KW - adolescent
KW - antioxidant
KW - carotenoid
KW - effect modifier
KW - malondialdehyde (MDA)
KW - physical performance
UR - http://www.scopus.com/inward/record.url?scp=85127399738&partnerID=8YFLogxK
U2 - 10.3390/ijerph19074296
DO - 10.3390/ijerph19074296
M3 - Article
C2 - 35409979
AN - SCOPUS:85127399738
SN - 1661-7827
VL - 19
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 7
M1 - 4296
ER -