Association of nutritional status with cognitive stage in the elderly Korean population: The Korean brain aging study for the early diagnosis and prediction of alzheimer’s disease

Jae Won Jang; Yeshin Kim; Yong Ho Choi; Jong Min Lee; Bora Yoon; Kyung Won Park; Si Eun Kim; Hee Jin Kim; Soo Jin Yoon; Jee Hyang Jeong; Eun Joo Kim; Na Yeon Jung; Jihye Hwang; Ju Hee Kang; Jin Yong Hong; Seong Hye Choi

doi:10.3988/jcn.2019.15.3.292

Association of nutritional status with cognitive stage in the elderly Korean population: The Korean brain aging study for the early diagnosis and prediction of alzheimer’s disease

Jae Won Jang, Yeshin Kim, Yong Ho Choi, Jong Min Lee, Bora Yoon, Kyung Won Park, Si Eun Kim, Hee Jin Kim, Soo Jin Yoon, Jee Hyang Jeong, Eun Joo Kim, Na Yeon Jung, Jihye Hwang, Ju Hee Kang, Jin Yong Hong, Seong Hye Choi

Department of Neurology

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8 Scopus citations

Abstract

Background and Purpose Epidemiological studies have suggested the presence of strong correlations among diet, lifestyle, and dementia onset. However, these studies have unfortunately had major limitations due to their inability to fully control the various potential con-founders affecting the nutritional status. The purpose of the current study was to determine the nutritional status of participants in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE) and to identify clinical risk factors for being at risk of malnutrition or being malnourished. Methods Baseline data from 212 participants [119 cognitively unimpaired (CU), 56 with mild cognitive impairment (MCI), and 37 with dementia] included in the KBASE database were analyzed. All participants underwent a comprehensive cognitive test and MRI at baseline. The presence of malnutrition at baseline was measured by the Mini Nutritional Assessment score. We examined the cross-sectional relationships of clinical findings with nutritional status using multiple logistic regression applied to variables for which p<0.2 in the univariate analysis. Differences in cortical thickness according to the nutritional status were also investigated. Results After adjustment for demographic, nutritional, and neuropsychological factors, participants with dementia had a significantly higher odds ratio (OR) for being at risk of malnutrition or being malnourished than CU participants [OR=5.98, 95% CI=1.20–32.97] whereas participants with MCI did not (OR=0.62, 95% CI=0.20–1.83). Cortical thinning in the at-risk/ malnutrition group was observed in the left temporal area. Conclusions Dementia was found to be an independent predictor for the risk of malnutrition compared with CU participants. Our findings further suggest that cortical thinning in left temporal regions is related to the nutritional status.

Original language	English
Pages (from-to)	292-300
Number of pages	9
Journal	Journal of Clinical Neurology (Korea)
Volume	15
Issue number	3
DOIs	https://doi.org/10.3988/jcn.2019.15.3.292
State	Published - Jul 2019

Bibliographical note

Funding Information:
This research was supported by the Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2014M3C7A 1064752) and by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI18C0479). And, this work was also supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (2016R1A2B301 6609).

Publisher Copyright:
© 2019 Korean Neurological Association.

Keywords

Cerebral cortex
Dementia
Nutritional status

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10.3988/jcn.2019.15.3.292

Cite this

Jang, J. W., Kim, Y., Choi, Y. H., Lee, J. M., Yoon, B., Park, K. W., Kim, S. E., Kim, H. J., Yoon, S. J., Jeong, J. H., Kim, E. J., Jung, N. Y., Hwang, J., Kang, J. H., Hong, J. Y., & Choi, S. H. (2019). Association of nutritional status with cognitive stage in the elderly Korean population: The Korean brain aging study for the early diagnosis and prediction of alzheimer’s disease. Journal of Clinical Neurology (Korea), 15(3), 292-300. https://doi.org/10.3988/jcn.2019.15.3.292

@article{1bbc3e4915234529b238cfef4cd3888b,

title = "Association of nutritional status with cognitive stage in the elderly Korean population: The Korean brain aging study for the early diagnosis and prediction of alzheimer{\textquoteright}s disease",

abstract = "Background and Purpose Epidemiological studies have suggested the presence of strong correlations among diet, lifestyle, and dementia onset. However, these studies have unfortunately had major limitations due to their inability to fully control the various potential con-founders affecting the nutritional status. The purpose of the current study was to determine the nutritional status of participants in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer{\textquoteright}s Disease (KBASE) and to identify clinical risk factors for being at risk of malnutrition or being malnourished. Methods Baseline data from 212 participants [119 cognitively unimpaired (CU), 56 with mild cognitive impairment (MCI), and 37 with dementia] included in the KBASE database were analyzed. All participants underwent a comprehensive cognitive test and MRI at baseline. The presence of malnutrition at baseline was measured by the Mini Nutritional Assessment score. We examined the cross-sectional relationships of clinical findings with nutritional status using multiple logistic regression applied to variables for which p<0.2 in the univariate analysis. Differences in cortical thickness according to the nutritional status were also investigated. Results After adjustment for demographic, nutritional, and neuropsychological factors, participants with dementia had a significantly higher odds ratio (OR) for being at risk of malnutrition or being malnourished than CU participants [OR=5.98, 95% CI=1.20–32.97] whereas participants with MCI did not (OR=0.62, 95% CI=0.20–1.83). Cortical thinning in the at-risk/ malnutrition group was observed in the left temporal area. Conclusions Dementia was found to be an independent predictor for the risk of malnutrition compared with CU participants. Our findings further suggest that cortical thinning in left temporal regions is related to the nutritional status.",

keywords = "Cerebral cortex, Dementia, Nutritional status",

author = "Jang, {Jae Won} and Yeshin Kim and Choi, {Yong Ho} and Lee, {Jong Min} and Bora Yoon and Park, {Kyung Won} and Kim, {Si Eun} and Kim, {Hee Jin} and Yoon, {Soo Jin} and Jeong, {Jee Hyang} and Kim, {Eun Joo} and Jung, {Na Yeon} and Jihye Hwang and Kang, {Ju Hee} and Hong, {Jin Yong} and Choi, {Seong Hye}",

note = "Funding Information: This research was supported by the Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2014M3C7A 1064752) and by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI18C0479). And, this work was also supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (2016R1A2B301 6609). Publisher Copyright: {\textcopyright} 2019 Korean Neurological Association.",

year = "2019",

month = jul,

doi = "10.3988/jcn.2019.15.3.292",

language = "English",

volume = "15",

pages = "292--300",

journal = "Journal of Clinical Neurology (Korea)",

issn = "1738-6586",

publisher = "Korean Neurological Association",

number = "3",

}

Jang, JW, Kim, Y, Choi, YH, Lee, JM, Yoon, B, Park, KW, Kim, SE, Kim, HJ, Yoon, SJ, Jeong, JH, Kim, EJ, Jung, NY, Hwang, J, Kang, JH, Hong, JY & Choi, SH 2019, 'Association of nutritional status with cognitive stage in the elderly Korean population: The Korean brain aging study for the early diagnosis and prediction of alzheimer’s disease', Journal of Clinical Neurology (Korea), vol. 15, no. 3, pp. 292-300. https://doi.org/10.3988/jcn.2019.15.3.292

Association of nutritional status with cognitive stage in the elderly Korean population: The Korean brain aging study for the early diagnosis and prediction of alzheimer’s disease. / Jang, Jae Won; Kim, Yeshin; Choi, Yong Ho et al.
In: Journal of Clinical Neurology (Korea), Vol. 15, No. 3, 07.2019, p. 292-300.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Association of nutritional status with cognitive stage in the elderly Korean population

T2 - The Korean brain aging study for the early diagnosis and prediction of alzheimer’s disease

AU - Jang, Jae Won

AU - Kim, Yeshin

AU - Choi, Yong Ho

AU - Lee, Jong Min

AU - Yoon, Bora

AU - Park, Kyung Won

AU - Kim, Si Eun

AU - Kim, Hee Jin

AU - Yoon, Soo Jin

AU - Jeong, Jee Hyang

AU - Kim, Eun Joo

AU - Jung, Na Yeon

AU - Hwang, Jihye

AU - Kang, Ju Hee

AU - Hong, Jin Yong

AU - Choi, Seong Hye

N1 - Funding Information: This research was supported by the Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2014M3C7A 1064752) and by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI18C0479). And, this work was also supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (2016R1A2B301 6609). Publisher Copyright: © 2019 Korean Neurological Association.

PY - 2019/7

Y1 - 2019/7

N2 - Background and Purpose Epidemiological studies have suggested the presence of strong correlations among diet, lifestyle, and dementia onset. However, these studies have unfortunately had major limitations due to their inability to fully control the various potential con-founders affecting the nutritional status. The purpose of the current study was to determine the nutritional status of participants in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE) and to identify clinical risk factors for being at risk of malnutrition or being malnourished. Methods Baseline data from 212 participants [119 cognitively unimpaired (CU), 56 with mild cognitive impairment (MCI), and 37 with dementia] included in the KBASE database were analyzed. All participants underwent a comprehensive cognitive test and MRI at baseline. The presence of malnutrition at baseline was measured by the Mini Nutritional Assessment score. We examined the cross-sectional relationships of clinical findings with nutritional status using multiple logistic regression applied to variables for which p<0.2 in the univariate analysis. Differences in cortical thickness according to the nutritional status were also investigated. Results After adjustment for demographic, nutritional, and neuropsychological factors, participants with dementia had a significantly higher odds ratio (OR) for being at risk of malnutrition or being malnourished than CU participants [OR=5.98, 95% CI=1.20–32.97] whereas participants with MCI did not (OR=0.62, 95% CI=0.20–1.83). Cortical thinning in the at-risk/ malnutrition group was observed in the left temporal area. Conclusions Dementia was found to be an independent predictor for the risk of malnutrition compared with CU participants. Our findings further suggest that cortical thinning in left temporal regions is related to the nutritional status.

AB - Background and Purpose Epidemiological studies have suggested the presence of strong correlations among diet, lifestyle, and dementia onset. However, these studies have unfortunately had major limitations due to their inability to fully control the various potential con-founders affecting the nutritional status. The purpose of the current study was to determine the nutritional status of participants in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE) and to identify clinical risk factors for being at risk of malnutrition or being malnourished. Methods Baseline data from 212 participants [119 cognitively unimpaired (CU), 56 with mild cognitive impairment (MCI), and 37 with dementia] included in the KBASE database were analyzed. All participants underwent a comprehensive cognitive test and MRI at baseline. The presence of malnutrition at baseline was measured by the Mini Nutritional Assessment score. We examined the cross-sectional relationships of clinical findings with nutritional status using multiple logistic regression applied to variables for which p<0.2 in the univariate analysis. Differences in cortical thickness according to the nutritional status were also investigated. Results After adjustment for demographic, nutritional, and neuropsychological factors, participants with dementia had a significantly higher odds ratio (OR) for being at risk of malnutrition or being malnourished than CU participants [OR=5.98, 95% CI=1.20–32.97] whereas participants with MCI did not (OR=0.62, 95% CI=0.20–1.83). Cortical thinning in the at-risk/ malnutrition group was observed in the left temporal area. Conclusions Dementia was found to be an independent predictor for the risk of malnutrition compared with CU participants. Our findings further suggest that cortical thinning in left temporal regions is related to the nutritional status.

KW - Cerebral cortex

KW - Dementia

KW - Nutritional status

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U2 - 10.3988/jcn.2019.15.3.292

DO - 10.3988/jcn.2019.15.3.292

M3 - Article

AN - SCOPUS:85071524325

SN - 1738-6586

VL - 15

SP - 292

EP - 300

JO - Journal of Clinical Neurology (Korea)

JF - Journal of Clinical Neurology (Korea)

IS - 3

ER -

Association of nutritional status with cognitive stage in the elderly Korean population: The Korean brain aging study for the early diagnosis and prediction of alzheimer’s disease

Abstract

Bibliographical note

Keywords

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