Association of atrial fibrillation with infectivity and severe complications of COVID-19: A nationwide cohort study

Jin Park, Jae Il Shin, Dong Hyeok Kim, Junbeom Park, Jimin Jeon, Jinkwon Kim, Tae Jin Song

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Infection is associated with the occurrence, recurrence, and progression of atrial fibrillation (AF), and is also closely related to poor prognosis. However, studies of the relationship between infectivity and severe complications of coronavirus infectious disease-19 (COVID-19) with a history of AF are limited. To estimate infectivity and severity of complications in COVID-19 patients with a history of AF, this study was done. From the Korean nationwide COVID-19 dataset, 212 678 participants with at least one severe acute respiratory syndrome coronavirus 2 (COVID-19) test were included between January 1 and June 4, 2020. AF was defined according to at least two outpatient hospital visits or one admission with an ICD-10 code of “I48” before the COVID-19 test. To investigate the association of AF with infectivity and severe complications of COVID-19, 1:4 ratio propensity score matching (PSM) was performed. Severe complications of COVID-19 were defined as a composite outcome of mechanical ventilation, intensive care unit admission, and death within 2 months after COVID-19 diagnosis. Among 212 678 participants who underwent the COVID-19 test, there were 7713 COVID-19 positive patients. After PSM, COVID-19 PCR positivity did not show a significant difference according to the presence of AF (odds ratio [OR]: 0.79, 95% confidence interval [CI]: [0.60–1.04]). Of 7713 COVID-19 patients, 62 (0.8%) had a history of AF and severe complications occurred in 444 (5.7%) patients. After PSM, AF was associated with the development of severe complications (OR: 2.04, 95% CI: [1.10–3.79]) and mortality (OR: 2.09, 95% CI: [1.01–4.31]) of COVID-19. We found that AF was associated with an increased risk of severe complications in COVID-19 infected patients.

Original languageEnglish
Pages (from-to)2422-2430
Number of pages9
JournalJournal of Medical Virology
Issue number6
StatePublished - Jun 2022

Bibliographical note

Publisher Copyright:
© 2022 Wiley Periodicals LLC.


  • COVID-19
  • atrial fibrillation
  • infectivity
  • intensive care unit
  • mechanical ventilation
  • mortality
  • prognosis


Dive into the research topics of 'Association of atrial fibrillation with infectivity and severe complications of COVID-19: A nationwide cohort study'. Together they form a unique fingerprint.

Cite this