Association between VEGFA gene polymorphisms and bleeding complications in patients maintaining therapeutic international normalized ratio

Jeong Yee, Woorim Kim, Byung Chul Chang, Jee Eun Chung, Kyung Eun Lee, Hye Sun Gwak

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Aim: This study was designed to identify the possible effects of VEGFA polymorphisms on the occurrence of bleeding complications in patients with mechanical heart valves who have achieved therapeutic international normalized ratio (INR). Materials & methods: 13 SNPs of VEGFA were analyzed. Uni- and multi-variate analyses were conducted to identify associations between polymorphisms and bleeding complications. Results & conclusion: Patients with the CC genotype of rs35410204 had an approximately tenfold higher bleeding complication than those with the T allele. For rs866236, patients who had wild-type homozygotes showed an approximately 2.9-fold higher bleeding complication than C allele carriers. This study demonstrated that bleeding complications during warfarin therapy are associated with VEGFA polymorphisms in patients with mechanical heart valves.

Original languageEnglish
Pages (from-to)659-667
Number of pages9
JournalPharmacogenomics
Volume20
Issue number9
DOIs
StatePublished - 2019

Bibliographical note

Funding Information:
This study was supported by Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education [grant number 2017R1D1A1B03034033]. The authors have no other relevant affiliations or financial involvement with any organisation or entity with a financial interest in or financial conflict with the subject matter or materials discussed in this manuscript apart from those disclosed.

Funding Information:
This study was supported by Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education [grant number 2017R1D1A1B03034033]. The authors have no other relevant affiliations or financial involvement with any organisation or entity with a financial interest in or financial conflict with the subject matter or materials discussed in this manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

Publisher Copyright:
© 2019 Future Medicine Ltd.

Keywords

  • VEGFA
  • bleeding
  • mechanical heart valve
  • therapeutic INR
  • warfarin

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