Association between VEGFA gene polymorphisms and bleeding complications in patients maintaining therapeutic international normalized ratio

Jeong Yee, Woorim Kim, Byung Chul Chang, Jee Eun Chung, Kyung Eun Lee, Hye Sun Gwak

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Aim: This study was designed to identify the possible effects of VEGFA polymorphisms on the occurrence of bleeding complications in patients with mechanical heart valves who have achieved therapeutic international normalized ratio (INR). Materials & methods: 13 SNPs of VEGFA were analyzed. Uni- and multi-variate analyses were conducted to identify associations between polymorphisms and bleeding complications. Results & conclusion: Patients with the CC genotype of rs35410204 had an approximately tenfold higher bleeding complication than those with the T allele. For rs866236, patients who had wild-type homozygotes showed an approximately 2.9-fold higher bleeding complication than C allele carriers. This study demonstrated that bleeding complications during warfarin therapy are associated with VEGFA polymorphisms in patients with mechanical heart valves.

Original languageEnglish
Pages (from-to)659-667
Number of pages9
JournalPharmacogenomics
Volume20
Issue number9
DOIs
StatePublished - 2019

Keywords

  • bleeding
  • mechanical heart valve
  • therapeutic INR
  • VEGFA
  • warfarin

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