Association between serum levels of uric acid and blood pressure tracking in childhood

Bohyun Park, Hye Ah Lee, Sung Hee Lee, Bo Mi Park, Eun Ae Park, Hae Soon Kim, Su Jin Cho, Hyesook Park

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

BACKGROUND Recent studies suggest that high levels of serum uric acid of very early life are a result of the in-utero environment and may lead to elevated blood pressure (BP) in adulthood. However, serum uric acid levels can change throughout life. We investigated the effect of serum uric acid levels in childhood on the BP tracking and analysed BP according to changes in serum uric acid levels in early life. METHODS A total of 449 children from the Ewha Birth and Growth Cohort study underwent at least 2 follow-up examinations. Data were collected across 3 check-up cycles. Serum uric acid levels, BP, and anthropometric characteristics were assessed at 3, 5, and 7 years of age. RESULTS Children with a serum uric acid level higher than the median values had significantly increased systolic BP (SBP) and diastolic BP at 3 years of age. Baseline serum uric acid levels measured at 3 years of age, significantly affected subsequent BP in the sex and body mass index adjusted longitudinal data analysis (P < 0.05). Considering the changing pattern of serum uric acid over time, subjects with high uric acid levels at both 3 and 5 years of age had the highest SBP at 7 years of age. CONCLUSIONS These findings suggest the importance of maintaining an adequate level of serum uric acids from the early life. Appropriate monitoring and intervention of uric acid levels in a high-risk group can reduce the risk of a future increased BP.

Original languageEnglish
Pages (from-to)713-718
Number of pages6
JournalAmerican Journal of Hypertension
Volume30
Issue number7
DOIs
StatePublished - Jul 2017

Keywords

  • blood pressure
  • early childhood
  • hypertension
  • intervention
  • longitudinal blood pressure
  • monitoring
  • uric acid.

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