Association between MKRN3 and LIN28B polymorphisms and precocious puberty

Bo Ram Yi; Hyun Jeong Kim; Hye Sook Park; Yoon Jeong Cho; Ju Young Kim; Jeong Yee; Jee Eun Chung; Joo Hee Kim; Kyung Eun Lee; Hye Sun Gwak

doi:10.1186/s12863-018-0658-z

Association between MKRN3 and LIN28B polymorphisms and precocious puberty

Bo Ram Yi, Hyun Jeong Kim, Hye Sook Park, Yoon Jeong Cho, Ju Young Kim, Jeong Yee, Jee Eun Chung, Joo Hee Kim, Kyung Eun Lee, Hye Sun Gwak

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: The present study aimed to investigate the association between MKRN3 and LIN28B gene polymorphisms and precocious puberty in Korean boys and girls. Results: Children 7 to 9 years of age in 2011 to 2012 who were part of the Ewha Birth & Growth Cohort Study were recruited for this study. A total of 103 girls and 70 boys were included in the analyses. Seven girls and 26 boys were identified to have precocious puberty. Among four single nucleotide polymorphisms (SNPs) of MKRN3 and two SNPs of LIN28B examined, three SNPs (rs2239669, rs6576457, and rs12441827) showed significant associations with precocious puberty in additive models in boys but no significance was found in any SNPs in girls. From the logistic regression analysis, boys with TT alleles in rs12441827 had about a four-times greater risk for precocious puberty when compared to C allele carriers (OR = 3.95, 95% CI = 1.27-12.32 in model 1). eQTL analysis revealed that SNPs of statistical significance from our study did not show the variation in expression profiles nor found in the database. Conclusions: This study supports the impact of MKRN3 SNP rs12441827 on precocious puberty in Korean boys. The results add a further aspect to genetic association in precocious puberty along with complex interactions of environmental, nutritional and socioeconomic factors.

Original language	English
Article number	47
Journal	BMC Genetics
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12863-018-0658-z
State	Published - 27 Jul 2018

Bibliographical note

Publisher Copyright:
© 2018 The Author(s).

Keywords

Lin-28 homolog B
Makorin RING finger protein 3
Precocious puberty
Single nucleotide polymorphism

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title = "Association between MKRN3 and LIN28B polymorphisms and precocious puberty",

abstract = "Background: The present study aimed to investigate the association between MKRN3 and LIN28B gene polymorphisms and precocious puberty in Korean boys and girls. Results: Children 7 to 9 years of age in 2011 to 2012 who were part of the Ewha Birth & Growth Cohort Study were recruited for this study. A total of 103 girls and 70 boys were included in the analyses. Seven girls and 26 boys were identified to have precocious puberty. Among four single nucleotide polymorphisms (SNPs) of MKRN3 and two SNPs of LIN28B examined, three SNPs (rs2239669, rs6576457, and rs12441827) showed significant associations with precocious puberty in additive models in boys but no significance was found in any SNPs in girls. From the logistic regression analysis, boys with TT alleles in rs12441827 had about a four-times greater risk for precocious puberty when compared to C allele carriers (OR = 3.95, 95% CI = 1.27-12.32 in model 1). eQTL analysis revealed that SNPs of statistical significance from our study did not show the variation in expression profiles nor found in the database. Conclusions: This study supports the impact of MKRN3 SNP rs12441827 on precocious puberty in Korean boys. The results add a further aspect to genetic association in precocious puberty along with complex interactions of environmental, nutritional and socioeconomic factors.",

keywords = "Lin-28 homolog B, Makorin RING finger protein 3, Precocious puberty, Single nucleotide polymorphism",

author = "Yi, {Bo Ram} and Kim, {Hyun Jeong} and Park, {Hye Sook} and Cho, {Yoon Jeong} and Kim, {Ju Young} and Jeong Yee and Chung, {Jee Eun} and Kim, {Joo Hee} and Lee, {Kyung Eun} and Gwak, {Hye Sun}",

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AU - Yi, Bo Ram

AU - Kim, Hyun Jeong

AU - Park, Hye Sook

AU - Cho, Yoon Jeong

AU - Kim, Ju Young

AU - Yee, Jeong

AU - Chung, Jee Eun

AU - Kim, Joo Hee

AU - Lee, Kyung Eun

AU - Gwak, Hye Sun

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N2 - Background: The present study aimed to investigate the association between MKRN3 and LIN28B gene polymorphisms and precocious puberty in Korean boys and girls. Results: Children 7 to 9 years of age in 2011 to 2012 who were part of the Ewha Birth & Growth Cohort Study were recruited for this study. A total of 103 girls and 70 boys were included in the analyses. Seven girls and 26 boys were identified to have precocious puberty. Among four single nucleotide polymorphisms (SNPs) of MKRN3 and two SNPs of LIN28B examined, three SNPs (rs2239669, rs6576457, and rs12441827) showed significant associations with precocious puberty in additive models in boys but no significance was found in any SNPs in girls. From the logistic regression analysis, boys with TT alleles in rs12441827 had about a four-times greater risk for precocious puberty when compared to C allele carriers (OR = 3.95, 95% CI = 1.27-12.32 in model 1). eQTL analysis revealed that SNPs of statistical significance from our study did not show the variation in expression profiles nor found in the database. Conclusions: This study supports the impact of MKRN3 SNP rs12441827 on precocious puberty in Korean boys. The results add a further aspect to genetic association in precocious puberty along with complex interactions of environmental, nutritional and socioeconomic factors.

AB - Background: The present study aimed to investigate the association between MKRN3 and LIN28B gene polymorphisms and precocious puberty in Korean boys and girls. Results: Children 7 to 9 years of age in 2011 to 2012 who were part of the Ewha Birth & Growth Cohort Study were recruited for this study. A total of 103 girls and 70 boys were included in the analyses. Seven girls and 26 boys were identified to have precocious puberty. Among four single nucleotide polymorphisms (SNPs) of MKRN3 and two SNPs of LIN28B examined, three SNPs (rs2239669, rs6576457, and rs12441827) showed significant associations with precocious puberty in additive models in boys but no significance was found in any SNPs in girls. From the logistic regression analysis, boys with TT alleles in rs12441827 had about a four-times greater risk for precocious puberty when compared to C allele carriers (OR = 3.95, 95% CI = 1.27-12.32 in model 1). eQTL analysis revealed that SNPs of statistical significance from our study did not show the variation in expression profiles nor found in the database. Conclusions: This study supports the impact of MKRN3 SNP rs12441827 on precocious puberty in Korean boys. The results add a further aspect to genetic association in precocious puberty along with complex interactions of environmental, nutritional and socioeconomic factors.

KW - Lin-28 homolog B

KW - Makorin RING finger protein 3

KW - Precocious puberty

KW - Single nucleotide polymorphism

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JO - BMC Genetics

JF - BMC Genetics

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ER -

Association between MKRN3 and LIN28B polymorphisms and precocious puberty

Abstract

Bibliographical note

Keywords

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