Association between human adenovirus-36 and lipid disorders in Korean schoolchildren

H. N. Na; Y. M. Hong; J. Kim; H. K. Kim; I. Jo; J. H. Nam

doi:10.1038/ijo.2009.207

Association between human adenovirus-36 and lipid disorders in Korean schoolchildren

H. N. Na, Y. M. Hong, J. Kim, H. K. Kim, I. Jo, J. H. Nam

Department of Molecular Medicine

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

Background: Although the human adenovirus-36 (Ad-36) has been associated with obesity and related lipid disorders in the United States, this association has yet to be identified in other countries. Therefore, we tried to determine whether Ad-36 is associated with obesity or lipid disorders in Korean schoolchildren.Method:A total of 318 Korean schoolchildren aged 6-15 years, who participated in the Ewha Womans University Obesity Research Study, were selected for a community-based cohort study. Non-obese and obese were defined as body mass index (BMI) 85th and 95th percentiles of the Korean reference BMI-for-age curves, respectively, according to International Obesity Task Force definitions. The cutoff points for lipid disorders were modified from the age-modified standards of the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP) III metabolic syndrome criteria. The Ad-36 antibody was measured using a serum neutralization assay.Results:More obese participants than non-obese participants tested positive for the Ad-36 antibody (28.57 vs 13.56%, respectively; P0.0174). Within the obese group, the participants who tested positive for the Ad-36 antibody had higher levels of triglycerides (TG) and total cholesterol than those who tested negative for the Ad-36 antibody (P0.001). However, these associations were not present in the non-obese group. The unadjusted odds ratio (OR) for Ad-36 antibody positivity was greater in obese participants than non-obese participants (OR2.550, 95% confidence interval (CI): 1.154-5.633). However, this OR seemed to be nonsignificant when age, sex and lipid variables were included in the analysis (OR1.752, 95% CI: 0.763-4.020). The unadjusted OR for the elevated TG was significantly higher in participants who were Ad-36 antibody-positive than those who were Ad-36 antibody-negative (OR2.511, 95% CI: 1.448-4.353). This trend remained constant even after adjustment for age, sex and obesity (OR2.328, 95% CI: 1.296-4.181).Conclusion:Ad-36 seems to be strongly associated with lipid disorders in Korean schoolchildren regardless of obesity.

Original language	English
Pages (from-to)	89-93
Number of pages	5
Journal	International Journal of Obesity
Volume	34
Issue number	1
DOIs	https://doi.org/10.1038/ijo.2009.207
State	Published - Jan 2010

Bibliographical note

Funding Information:
The research was supported by the Catholic University of Korea, Research Fund 2009, Korea Rural Development Administration, by grant from the GRRC of the Catholic University of Korea and was supported financially by MKE and KOTEF through the Human Resource Training Project for Strategic Technology. Ha-Na Na was supported by grant from the health fellowship foundation of the Yuhan Corporation.

Keywords

Human adenovirus-36
Korean schoolchildren
Lipid disorders
Total cholesterol
Triglycerides

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ijo.2009.207

Cite this

@article{1277f12840d94ecabe97d7883117cf53,

title = "Association between human adenovirus-36 and lipid disorders in Korean schoolchildren",

abstract = "Background: Although the human adenovirus-36 (Ad-36) has been associated with obesity and related lipid disorders in the United States, this association has yet to be identified in other countries. Therefore, we tried to determine whether Ad-36 is associated with obesity or lipid disorders in Korean schoolchildren.Method:A total of 318 Korean schoolchildren aged 6-15 years, who participated in the Ewha Womans University Obesity Research Study, were selected for a community-based cohort study. Non-obese and obese were defined as body mass index (BMI) 85th and 95th percentiles of the Korean reference BMI-for-age curves, respectively, according to International Obesity Task Force definitions. The cutoff points for lipid disorders were modified from the age-modified standards of the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP) III metabolic syndrome criteria. The Ad-36 antibody was measured using a serum neutralization assay.Results:More obese participants than non-obese participants tested positive for the Ad-36 antibody (28.57 vs 13.56%, respectively; P0.0174). Within the obese group, the participants who tested positive for the Ad-36 antibody had higher levels of triglycerides (TG) and total cholesterol than those who tested negative for the Ad-36 antibody (P0.001). However, these associations were not present in the non-obese group. The unadjusted odds ratio (OR) for Ad-36 antibody positivity was greater in obese participants than non-obese participants (OR2.550, 95% confidence interval (CI): 1.154-5.633). However, this OR seemed to be nonsignificant when age, sex and lipid variables were included in the analysis (OR1.752, 95% CI: 0.763-4.020). The unadjusted OR for the elevated TG was significantly higher in participants who were Ad-36 antibody-positive than those who were Ad-36 antibody-negative (OR2.511, 95% CI: 1.448-4.353). This trend remained constant even after adjustment for age, sex and obesity (OR2.328, 95% CI: 1.296-4.181).Conclusion:Ad-36 seems to be strongly associated with lipid disorders in Korean schoolchildren regardless of obesity.",

keywords = "Human adenovirus-36, Korean schoolchildren, Lipid disorders, Total cholesterol, Triglycerides",

author = "Na, {H. N.} and Hong, {Y. M.} and J. Kim and Kim, {H. K.} and I. Jo and Nam, {J. H.}",

note = "Funding Information: The research was supported by the Catholic University of Korea, Research Fund 2009, Korea Rural Development Administration, by grant from the GRRC of the Catholic University of Korea and was supported financially by MKE and KOTEF through the Human Resource Training Project for Strategic Technology. Ha-Na Na was supported by grant from the health fellowship foundation of the Yuhan Corporation.",

year = "2010",

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doi = "10.1038/ijo.2009.207",

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AU - Na, H. N.

AU - Hong, Y. M.

AU - Kim, J.

AU - Kim, H. K.

AU - Jo, I.

AU - Nam, J. H.

N1 - Funding Information: The research was supported by the Catholic University of Korea, Research Fund 2009, Korea Rural Development Administration, by grant from the GRRC of the Catholic University of Korea and was supported financially by MKE and KOTEF through the Human Resource Training Project for Strategic Technology. Ha-Na Na was supported by grant from the health fellowship foundation of the Yuhan Corporation.

PY - 2010/1

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N2 - Background: Although the human adenovirus-36 (Ad-36) has been associated with obesity and related lipid disorders in the United States, this association has yet to be identified in other countries. Therefore, we tried to determine whether Ad-36 is associated with obesity or lipid disorders in Korean schoolchildren.Method:A total of 318 Korean schoolchildren aged 6-15 years, who participated in the Ewha Womans University Obesity Research Study, were selected for a community-based cohort study. Non-obese and obese were defined as body mass index (BMI) 85th and 95th percentiles of the Korean reference BMI-for-age curves, respectively, according to International Obesity Task Force definitions. The cutoff points for lipid disorders were modified from the age-modified standards of the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP) III metabolic syndrome criteria. The Ad-36 antibody was measured using a serum neutralization assay.Results:More obese participants than non-obese participants tested positive for the Ad-36 antibody (28.57 vs 13.56%, respectively; P0.0174). Within the obese group, the participants who tested positive for the Ad-36 antibody had higher levels of triglycerides (TG) and total cholesterol than those who tested negative for the Ad-36 antibody (P0.001). However, these associations were not present in the non-obese group. The unadjusted odds ratio (OR) for Ad-36 antibody positivity was greater in obese participants than non-obese participants (OR2.550, 95% confidence interval (CI): 1.154-5.633). However, this OR seemed to be nonsignificant when age, sex and lipid variables were included in the analysis (OR1.752, 95% CI: 0.763-4.020). The unadjusted OR for the elevated TG was significantly higher in participants who were Ad-36 antibody-positive than those who were Ad-36 antibody-negative (OR2.511, 95% CI: 1.448-4.353). This trend remained constant even after adjustment for age, sex and obesity (OR2.328, 95% CI: 1.296-4.181).Conclusion:Ad-36 seems to be strongly associated with lipid disorders in Korean schoolchildren regardless of obesity.

AB - Background: Although the human adenovirus-36 (Ad-36) has been associated with obesity and related lipid disorders in the United States, this association has yet to be identified in other countries. Therefore, we tried to determine whether Ad-36 is associated with obesity or lipid disorders in Korean schoolchildren.Method:A total of 318 Korean schoolchildren aged 6-15 years, who participated in the Ewha Womans University Obesity Research Study, were selected for a community-based cohort study. Non-obese and obese were defined as body mass index (BMI) 85th and 95th percentiles of the Korean reference BMI-for-age curves, respectively, according to International Obesity Task Force definitions. The cutoff points for lipid disorders were modified from the age-modified standards of the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP) III metabolic syndrome criteria. The Ad-36 antibody was measured using a serum neutralization assay.Results:More obese participants than non-obese participants tested positive for the Ad-36 antibody (28.57 vs 13.56%, respectively; P0.0174). Within the obese group, the participants who tested positive for the Ad-36 antibody had higher levels of triglycerides (TG) and total cholesterol than those who tested negative for the Ad-36 antibody (P0.001). However, these associations were not present in the non-obese group. The unadjusted odds ratio (OR) for Ad-36 antibody positivity was greater in obese participants than non-obese participants (OR2.550, 95% confidence interval (CI): 1.154-5.633). However, this OR seemed to be nonsignificant when age, sex and lipid variables were included in the analysis (OR1.752, 95% CI: 0.763-4.020). The unadjusted OR for the elevated TG was significantly higher in participants who were Ad-36 antibody-positive than those who were Ad-36 antibody-negative (OR2.511, 95% CI: 1.448-4.353). This trend remained constant even after adjustment for age, sex and obesity (OR2.328, 95% CI: 1.296-4.181).Conclusion:Ad-36 seems to be strongly associated with lipid disorders in Korean schoolchildren regardless of obesity.

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KW - Korean schoolchildren

KW - Lipid disorders

KW - Total cholesterol

KW - Triglycerides

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Association between human adenovirus-36 and lipid disorders in Korean schoolchildren

Abstract

Bibliographical note

Keywords

UN SDGs

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