Association between human adenovirus-36 and lipid disorders in Korean schoolchildren

H. N. Na, Y. M. Hong, J. Kim, H. K. Kim, I. Jo, J. H. Nam

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83 Scopus citations

Abstract

Background: Although the human adenovirus-36 (Ad-36) has been associated with obesity and related lipid disorders in the United States, this association has yet to be identified in other countries. Therefore, we tried to determine whether Ad-36 is associated with obesity or lipid disorders in Korean schoolchildren.Method:A total of 318 Korean schoolchildren aged 6-15 years, who participated in the Ewha Womans University Obesity Research Study, were selected for a community-based cohort study. Non-obese and obese were defined as body mass index (BMI) 85th and 95th percentiles of the Korean reference BMI-for-age curves, respectively, according to International Obesity Task Force definitions. The cutoff points for lipid disorders were modified from the age-modified standards of the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP) III metabolic syndrome criteria. The Ad-36 antibody was measured using a serum neutralization assay.Results:More obese participants than non-obese participants tested positive for the Ad-36 antibody (28.57 vs 13.56%, respectively; P0.0174). Within the obese group, the participants who tested positive for the Ad-36 antibody had higher levels of triglycerides (TG) and total cholesterol than those who tested negative for the Ad-36 antibody (P0.001). However, these associations were not present in the non-obese group. The unadjusted odds ratio (OR) for Ad-36 antibody positivity was greater in obese participants than non-obese participants (OR2.550, 95% confidence interval (CI): 1.154-5.633). However, this OR seemed to be nonsignificant when age, sex and lipid variables were included in the analysis (OR1.752, 95% CI: 0.763-4.020). The unadjusted OR for the elevated TG was significantly higher in participants who were Ad-36 antibody-positive than those who were Ad-36 antibody-negative (OR2.511, 95% CI: 1.448-4.353). This trend remained constant even after adjustment for age, sex and obesity (OR2.328, 95% CI: 1.296-4.181).Conclusion:Ad-36 seems to be strongly associated with lipid disorders in Korean schoolchildren regardless of obesity.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalInternational Journal of Obesity
Volume34
Issue number1
DOIs
StatePublished - Jan 2010

Bibliographical note

Funding Information:
The research was supported by the Catholic University of Korea, Research Fund 2009, Korea Rural Development Administration, by grant from the GRRC of the Catholic University of Korea and was supported financially by MKE and KOTEF through the Human Resource Training Project for Strategic Technology. Ha-Na Na was supported by grant from the health fellowship foundation of the Yuhan Corporation.

Keywords

  • Human adenovirus-36
  • Korean schoolchildren
  • Lipid disorders
  • Total cholesterol
  • Triglycerides

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