Association between ESR1 rs1884051 polymorphism and dietary total energy and plant protein intake on obesity in Korean men

Miae Doo, Yangha Kim

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

ESR1 has been listed in the Human Obesity Gene Map as candidate gene associated with obesity. Thus, in this study, we investigated the effect of the ESR1 rs1884051 polymorphism on obesity-related variables, together with their modulations by dietary intake in Korean men. The obesity-related variables and dietary intake of 3,039 Korean men aged 40-59 years from KoGES database were analyzed. Body weight (P = 0.007), BMI (P = 0.003), waist-hip ratio (= 0.011), fat body mass (P = 0.010), and body fat percentage (P = 0.040) were significantly lower in subjects with the minor T allele of ESR1 rs1884051 than in subjects carrying the C allele. Moreover, the rs1884051 T allele was associated with a decreased risk of obesity prevalence (P = 0.040). Among the subjects whose total energy intake was below the median, carrier of the minor T allele of ESR1 rs1884051 had a lower BMI (P = 0.003) when compared with subjects carrying the C allele. In addition, among subjects whose plant protein intake was above the median, carrier of the minor T allele of ESR1 rs1884051 had a lower BMI (P = 0.044) compared with subjects carrying the C allele. Our findings demonstrate that there is a significant association between the ESR1 rs1884051 variant and obesity-related variables and this association can be potentially modified by dietary energy and plant protein intake.

Original languageEnglish
Pages (from-to)527-532
Number of pages6
JournalNutrition Research and Practice
Volume5
Issue number6
DOIs
StatePublished - Dec 2011

Keywords

  • BMI
  • Dietary intake
  • ESR1 gene
  • Obesity
  • Polymorphism

Fingerprint

Dive into the research topics of 'Association between ESR1 rs1884051 polymorphism and dietary total energy and plant protein intake on obesity in Korean men'. Together they form a unique fingerprint.

Cite this