Association Between Clinical Burden and Blood Eosinophil Counts in Asthma: Findings From a Korean Adult Asthma Cohort

Mi Yeong Kim; Eun Jung Jo; Sujeong Kim; Min Hye Kim; Jae Woo Jung; Joo Hee Kim; Ji Yong Moon; Jae Woo Kwon; Jae Hyun Lee; Chan Sun Park; Hyun Jung Jin; Yoo Seob Shin; Sae Hoon Kim; Young Joo Cho; Jung Won Park; Sang Heon Cho; Tae Bum Kim; Hye Kyung Park

doi:10.3346/JKMS.2022.37.E57

Association Between Clinical Burden and Blood Eosinophil Counts in Asthma: Findings From a Korean Adult Asthma Cohort

Mi Yeong Kim, Eun Jung Jo, Sujeong Kim, Min Hye Kim, Jae Woo Jung, Joo Hee Kim, Ji Yong Moon, Jae Woo Kwon, Jae Hyun Lee, Chan Sun Park, Hyun Jung Jin, Yoo Seob Shin, Sae Hoon Kim, Young Joo Cho, Jung Won Park, Sang Heon Cho, Tae Bum Kim, Hye Kyung Park

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Some reports have suggested that the clinical and economic burdens of asthma are associated with blood eosinophil levels. The association between clinical burden and blood eosinophil counts were evaluated in a Korean adult asthma cohort. Methods: Clinical information including blood eosinophil counts that were not affected by systemic corticosteroids were extracted from the Cohort for Reality and Evolution of Adult Asthma in Korea database. Clinical burden was defined as 1) asthma control status, 2) medication demand and 3) acute exacerbation (AE) events during 1 consecutive year after enrollment. All patients were divided into atopic and non-atopic asthmatics. The associations between asthma outcomes and the blood eosinophil count were evaluated. Results: In total, 302 patients (124 atopic and 178 non-atopic asthmatics) were enrolled. In all asthmatics, the risk of severe AE was higher in patients with blood eosinophil levels < 100 cells/μL than in patients with levels ≥ 100 cells/μL (odds ratio [OR], 5.406; 95% confidence interval [CI], 1.266–23.078; adjusted P = 0.023). Among atopic asthmatics, the risk of moderate AE was higher in patients with blood eosinophil levels ≥ 300 cells/μL than in patients with levels < 300 cells/μL (OR, 3.558; 95% CI, 1.083–11.686; adjusted P = 0.036). Among non-atopic asthmatics, the risk of medication of Global Initiative for Asthma (GINA) steps 4 or 5 was higher in patients with high blood eosinophil levels than in patients with low blood eosinophil levels at cutoffs of 100, 200, 300, 400, and 500 cells/μL. Conclusion: The baseline blood eosinophil count may predict the future clinical burden of asthma.

Original language	English
Article number	e57
Journal	Journal of Korean Medical Science
Volume	37
Issue number	7
DOIs	https://doi.org/10.3346/JKMS.2022.37.E57
State	Published - 2022

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (2019M3E5D3073365).

Funding Information:
We thank the members of the study centers for participating in this study. The COREA Study Group includes the following investigators: Woo-Jung Song, Hyouk-Soo Kwon, and You Sook Cho (Asan Medical Center, University of Ulsan, Seoul, Korea); Byoung Whui Choi (Chung-Ang University, Seoul, Korea); An-Soo Jang (Soonchunhyang University Bucheon Hospital, Bucheon, Korea); Sang-Hoon Kim and So Young Park (Eulji University, Seoul, Korea); Taehoon Lee (University of Ulsan, Ulsan, Korea); Jeong-Hee Choi (Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea); Young-Hee Nam (Dong-A University, Busan, Korea); Sun-Young Yoon (Konkuk University Chungju Hospital, Chungju, Korea); Min-Suk Yang (Seoul National University Boramae Medical Center, Seoul, Korea); Jaechun Lee (Jeju National University, Jeju, Korea); Gyu Young Hur (Korea University, Seoul, Korea); Hee-Kyoo Kim (Kosin University, Busan, Korea); and Sang Ha Kim (Yonsei University, Wonju, Korea)

Publisher Copyright:
© 2022 The Korean Academy of Medical Sciences

Keywords

Asthma
Blood eosinophils
Clinical burden

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10.3346/JKMS.2022.37.E57

Cite this

Kim, M. Y., Jo, E. J., Kim, S., Kim, M. H., Jung, J. W., Kim, J. H., Moon, J. Y., Kwon, J. W., Lee, J. H., Park, C. S., Jin, H. J., Shin, Y. S., Kim, S. H., Cho, Y. J., Park, J. W., Cho, S. H., Kim, T. B., & Park, H. K. (2022). Association Between Clinical Burden and Blood Eosinophil Counts in Asthma: Findings From a Korean Adult Asthma Cohort. Journal of Korean Medical Science, 37(7), Article e57. https://doi.org/10.3346/JKMS.2022.37.E57

@article{9001c31a158b4ef9a1aad185fc34d4db,

title = "Association Between Clinical Burden and Blood Eosinophil Counts in Asthma: Findings From a Korean Adult Asthma Cohort",

abstract = "Background: Some reports have suggested that the clinical and economic burdens of asthma are associated with blood eosinophil levels. The association between clinical burden and blood eosinophil counts were evaluated in a Korean adult asthma cohort. Methods: Clinical information including blood eosinophil counts that were not affected by systemic corticosteroids were extracted from the Cohort for Reality and Evolution of Adult Asthma in Korea database. Clinical burden was defined as 1) asthma control status, 2) medication demand and 3) acute exacerbation (AE) events during 1 consecutive year after enrollment. All patients were divided into atopic and non-atopic asthmatics. The associations between asthma outcomes and the blood eosinophil count were evaluated. Results: In total, 302 patients (124 atopic and 178 non-atopic asthmatics) were enrolled. In all asthmatics, the risk of severe AE was higher in patients with blood eosinophil levels < 100 cells/μL than in patients with levels ≥ 100 cells/μL (odds ratio [OR], 5.406; 95% confidence interval [CI], 1.266–23.078; adjusted P = 0.023). Among atopic asthmatics, the risk of moderate AE was higher in patients with blood eosinophil levels ≥ 300 cells/μL than in patients with levels < 300 cells/μL (OR, 3.558; 95% CI, 1.083–11.686; adjusted P = 0.036). Among non-atopic asthmatics, the risk of medication of Global Initiative for Asthma (GINA) steps 4 or 5 was higher in patients with high blood eosinophil levels than in patients with low blood eosinophil levels at cutoffs of 100, 200, 300, 400, and 500 cells/μL. Conclusion: The baseline blood eosinophil count may predict the future clinical burden of asthma.",

keywords = "Asthma, Blood eosinophils, Clinical burden",

author = "Kim, {Mi Yeong} and Jo, {Eun Jung} and Sujeong Kim and Kim, {Min Hye} and Jung, {Jae Woo} and Kim, {Joo Hee} and Moon, {Ji Yong} and Kwon, {Jae Woo} and Lee, {Jae Hyun} and Park, {Chan Sun} and Jin, {Hyun Jung} and Shin, {Yoo Seob} and Kim, {Sae Hoon} and Cho, {Young Joo} and Park, {Jung Won} and Cho, {Sang Heon} and Kim, {Tae Bum} and Park, {Hye Kyung}",

note = "Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (2019M3E5D3073365). Funding Information: We thank the members of the study centers for participating in this study. The COREA Study Group includes the following investigators: Woo-Jung Song, Hyouk-Soo Kwon, and You Sook Cho (Asan Medical Center, University of Ulsan, Seoul, Korea); Byoung Whui Choi (Chung-Ang University, Seoul, Korea); An-Soo Jang (Soonchunhyang University Bucheon Hospital, Bucheon, Korea); Sang-Hoon Kim and So Young Park (Eulji University, Seoul, Korea); Taehoon Lee (University of Ulsan, Ulsan, Korea); Jeong-Hee Choi (Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea); Young-Hee Nam (Dong-A University, Busan, Korea); Sun-Young Yoon (Konkuk University Chungju Hospital, Chungju, Korea); Min-Suk Yang (Seoul National University Boramae Medical Center, Seoul, Korea); Jaechun Lee (Jeju National University, Jeju, Korea); Gyu Young Hur (Korea University, Seoul, Korea); Hee-Kyoo Kim (Kosin University, Busan, Korea); and Sang Ha Kim (Yonsei University, Wonju, Korea) Publisher Copyright: {\textcopyright} 2022 The Korean Academy of Medical Sciences",

year = "2022",

doi = "10.3346/JKMS.2022.37.E57",

language = "English",

volume = "37",

journal = "Journal of Korean Medical Science",

issn = "1011-8934",

publisher = "Korean Academy of Medical Science",

number = "7",

}

Kim, MY, Jo, EJ, Kim, S, Kim, MH, Jung, JW, Kim, JH, Moon, JY, Kwon, JW, Lee, JH, Park, CS, Jin, HJ, Shin, YS, Kim, SH, Cho, YJ, Park, JW, Cho, SH, Kim, TB & Park, HK 2022, 'Association Between Clinical Burden and Blood Eosinophil Counts in Asthma: Findings From a Korean Adult Asthma Cohort', Journal of Korean Medical Science, vol. 37, no. 7, e57. https://doi.org/10.3346/JKMS.2022.37.E57

TY - JOUR

T1 - Association Between Clinical Burden and Blood Eosinophil Counts in Asthma

T2 - Findings From a Korean Adult Asthma Cohort

AU - Kim, Mi Yeong

AU - Jo, Eun Jung

AU - Kim, Sujeong

AU - Kim, Min Hye

AU - Jung, Jae Woo

AU - Kim, Joo Hee

AU - Moon, Ji Yong

AU - Kwon, Jae Woo

AU - Lee, Jae Hyun

AU - Park, Chan Sun

AU - Jin, Hyun Jung

AU - Shin, Yoo Seob

AU - Kim, Sae Hoon

AU - Cho, Young Joo

AU - Park, Jung Won

AU - Cho, Sang Heon

AU - Kim, Tae Bum

AU - Park, Hye Kyung

N1 - Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (2019M3E5D3073365). Funding Information: We thank the members of the study centers for participating in this study. The COREA Study Group includes the following investigators: Woo-Jung Song, Hyouk-Soo Kwon, and You Sook Cho (Asan Medical Center, University of Ulsan, Seoul, Korea); Byoung Whui Choi (Chung-Ang University, Seoul, Korea); An-Soo Jang (Soonchunhyang University Bucheon Hospital, Bucheon, Korea); Sang-Hoon Kim and So Young Park (Eulji University, Seoul, Korea); Taehoon Lee (University of Ulsan, Ulsan, Korea); Jeong-Hee Choi (Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea); Young-Hee Nam (Dong-A University, Busan, Korea); Sun-Young Yoon (Konkuk University Chungju Hospital, Chungju, Korea); Min-Suk Yang (Seoul National University Boramae Medical Center, Seoul, Korea); Jaechun Lee (Jeju National University, Jeju, Korea); Gyu Young Hur (Korea University, Seoul, Korea); Hee-Kyoo Kim (Kosin University, Busan, Korea); and Sang Ha Kim (Yonsei University, Wonju, Korea) Publisher Copyright: © 2022 The Korean Academy of Medical Sciences

PY - 2022

Y1 - 2022

N2 - Background: Some reports have suggested that the clinical and economic burdens of asthma are associated with blood eosinophil levels. The association between clinical burden and blood eosinophil counts were evaluated in a Korean adult asthma cohort. Methods: Clinical information including blood eosinophil counts that were not affected by systemic corticosteroids were extracted from the Cohort for Reality and Evolution of Adult Asthma in Korea database. Clinical burden was defined as 1) asthma control status, 2) medication demand and 3) acute exacerbation (AE) events during 1 consecutive year after enrollment. All patients were divided into atopic and non-atopic asthmatics. The associations between asthma outcomes and the blood eosinophil count were evaluated. Results: In total, 302 patients (124 atopic and 178 non-atopic asthmatics) were enrolled. In all asthmatics, the risk of severe AE was higher in patients with blood eosinophil levels < 100 cells/μL than in patients with levels ≥ 100 cells/μL (odds ratio [OR], 5.406; 95% confidence interval [CI], 1.266–23.078; adjusted P = 0.023). Among atopic asthmatics, the risk of moderate AE was higher in patients with blood eosinophil levels ≥ 300 cells/μL than in patients with levels < 300 cells/μL (OR, 3.558; 95% CI, 1.083–11.686; adjusted P = 0.036). Among non-atopic asthmatics, the risk of medication of Global Initiative for Asthma (GINA) steps 4 or 5 was higher in patients with high blood eosinophil levels than in patients with low blood eosinophil levels at cutoffs of 100, 200, 300, 400, and 500 cells/μL. Conclusion: The baseline blood eosinophil count may predict the future clinical burden of asthma.

AB - Background: Some reports have suggested that the clinical and economic burdens of asthma are associated with blood eosinophil levels. The association between clinical burden and blood eosinophil counts were evaluated in a Korean adult asthma cohort. Methods: Clinical information including blood eosinophil counts that were not affected by systemic corticosteroids were extracted from the Cohort for Reality and Evolution of Adult Asthma in Korea database. Clinical burden was defined as 1) asthma control status, 2) medication demand and 3) acute exacerbation (AE) events during 1 consecutive year after enrollment. All patients were divided into atopic and non-atopic asthmatics. The associations between asthma outcomes and the blood eosinophil count were evaluated. Results: In total, 302 patients (124 atopic and 178 non-atopic asthmatics) were enrolled. In all asthmatics, the risk of severe AE was higher in patients with blood eosinophil levels < 100 cells/μL than in patients with levels ≥ 100 cells/μL (odds ratio [OR], 5.406; 95% confidence interval [CI], 1.266–23.078; adjusted P = 0.023). Among atopic asthmatics, the risk of moderate AE was higher in patients with blood eosinophil levels ≥ 300 cells/μL than in patients with levels < 300 cells/μL (OR, 3.558; 95% CI, 1.083–11.686; adjusted P = 0.036). Among non-atopic asthmatics, the risk of medication of Global Initiative for Asthma (GINA) steps 4 or 5 was higher in patients with high blood eosinophil levels than in patients with low blood eosinophil levels at cutoffs of 100, 200, 300, 400, and 500 cells/μL. Conclusion: The baseline blood eosinophil count may predict the future clinical burden of asthma.

KW - Asthma

KW - Blood eosinophils

KW - Clinical burden

UR - http://www.scopus.com/inward/record.url?scp=85125154941&partnerID=8YFLogxK

U2 - 10.3346/JKMS.2022.37.E57

DO - 10.3346/JKMS.2022.37.E57

M3 - Article

C2 - 35191233

AN - SCOPUS:85125154941

SN - 1011-8934

VL - 37

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

IS - 7

M1 - e57

ER -

Association Between Clinical Burden and Blood Eosinophil Counts in Asthma: Findings From a Korean Adult Asthma Cohort

Abstract

Bibliographical note

Keywords

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