TY - JOUR
T1 - Association between Blood Pressure and Carotid Intima-Media Thickness
AU - Lim, Sun Min
AU - Kim, Hyeon Chang
AU - Lee, Hoon Sang
AU - Lee, Joo Young
AU - Suh, Mina
AU - Ahn, Song Vogue
N1 - Funding Information:
Supported by a faculty research grant from Yonsei University College of Medicine in 2006 (20060067). The authors declare no conflicts of interest.
PY - 2009/5
Y1 - 2009/5
N2 - Objective: To investigate the association between blood pressure and carotid intima-media thickness (IMT) in healthy adolescents. Study design: Study participants included 285 first-year high school students (mean age, 15.2 years) at a rural high school in Korea. Systolic and diastolic blood pressure (SBP and DBP) were measured with an oscillometric automated sphygmomanometer. The carotid arteries were evaluated with high-resolution B-mode ultrasound scanning. IMT value was determined with the average of the maximal IMT at each common carotid artery. Increased IMT was defined as sex-specific top quartile. The odds ratio (OR) for increased IMT per 1 SD increase of SBP and DBP was estimated after adjusting for age, sex, body mass index, waist circumference, fasting glucose level, and total/high-density lipoprotein cholesterol ratio. Results: Adjusted OR for increased IMT was 1.70 (P = .003) per 12.4 mm Hg SBP and 1.25 (P = .125) per 7.0 mm Hg DBP. When the analyses were performed by sex, increased IMT was associated with both SBP (OR, 2.67; P = .003) and DBP (OR, 1.68; P = .019) in girls, but it was not associated with either SBP (OR, 1.46; P = .093) or DBP (OR, 0.99; P = .972) in boys. Conclusion: These results suggest that higher blood pressure level may be associated with increased carotid IMT in apparently healthy adolescents.
AB - Objective: To investigate the association between blood pressure and carotid intima-media thickness (IMT) in healthy adolescents. Study design: Study participants included 285 first-year high school students (mean age, 15.2 years) at a rural high school in Korea. Systolic and diastolic blood pressure (SBP and DBP) were measured with an oscillometric automated sphygmomanometer. The carotid arteries were evaluated with high-resolution B-mode ultrasound scanning. IMT value was determined with the average of the maximal IMT at each common carotid artery. Increased IMT was defined as sex-specific top quartile. The odds ratio (OR) for increased IMT per 1 SD increase of SBP and DBP was estimated after adjusting for age, sex, body mass index, waist circumference, fasting glucose level, and total/high-density lipoprotein cholesterol ratio. Results: Adjusted OR for increased IMT was 1.70 (P = .003) per 12.4 mm Hg SBP and 1.25 (P = .125) per 7.0 mm Hg DBP. When the analyses were performed by sex, increased IMT was associated with both SBP (OR, 2.67; P = .003) and DBP (OR, 1.68; P = .019) in girls, but it was not associated with either SBP (OR, 1.46; P = .093) or DBP (OR, 0.99; P = .972) in boys. Conclusion: These results suggest that higher blood pressure level may be associated with increased carotid IMT in apparently healthy adolescents.
UR - http://www.scopus.com/inward/record.url?scp=64149084025&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2008.10.047
DO - 10.1016/j.jpeds.2008.10.047
M3 - Article
C2 - 19101684
AN - SCOPUS:64149084025
SN - 0022-3476
VL - 154
SP - 667-671.e1
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 5
ER -