Association between ß2-adrenergic receptor gene polymorphisms and adverse events of ritodrine in the treatment of preterm labor: A prospective observational study

Jee Eun Chung, Soo An Choi, Han Sung Hwang, Jin Young Park, Kyung Eun Lee, Jeong Yee, Young Ju Kim, Hye Sun Gwak

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Ritodrine, a tocolytic β2-agonist, has been used extensively in Europe and Asia despite its safety concerns. This study was designed to identify associations between β2-adrenergic receptor (ADRB2) polymorphisms and adverse drug events (ADEs) in patients with preterm labor treated with ritodrine. Results: This follow-up study was prospectively conducted at Ewha Womans University Mokdong Hospital in Korea. Five single nucleotide polymorphisms (SNPs) of the ADRB2 gene (rs1042713, rs1042714, rs1042717, rs1042718, and rs1042719) were analyzed in 186 pregnant women with preterm labor. Patients with the AA genotype of rs1042717 had significantly lower incidence of ADEs compared to those with the G allele (p = 0.009). In multivariate analysis, one of the predictors of ADEs was the maximum infusion rate of ritodrine (AOR 4.47, 95% CI 1.31-15.25). Rs1042719 was also a significant factor for ritodrine-induced ADEs. The CC genotype carriers had 78% decreased risk of ADEs compared to those with other genotypes. Conclusions: This study demonstrates that ADEs induced by ritodrine are associated with ADRB2 gene polymorphisms, as well as the infusion rate of ritodrine in pregnant women with preterm labor.

Original languageEnglish
Article number96
JournalBMC Genetics
Volume18
Issue number1
DOIs
StatePublished - 13 Nov 2017

Bibliographical note

Funding Information:
This work was supported by a grant from the Korea Health Industry Development Institute (KHIDI) (No. HI14C0306), funded by the Ministry of Health and Welfare, Republic of Korea.

Publisher Copyright:
© 2017 The Author(s).

Keywords

  • Adverse drug events
  • Gene polymorphism
  • Ritodrine
  • Tocolysis
  • β2-adrenergic receptor
  • β2-agonist

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