Aspirin-intolerant asthma in the Korean population: Prevalence and characteristics based on a questionnaire survey

Ji Yong Moon, Sang Heon Kim, Tae Bum Kim, Sae Hoon Kim, Yoon Seok Chang, Jae Hyun Lee, You Sook Cho, Jung Won Park, An Soo Jang, Choon Sik Park, Dong Ho Nahm, Young Joo Cho, Sang Heon Cho, Byoung Whui Choi, Hee Bom Moon, Ho Joo Yoon

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background: Aspirin-intolerant asthma is a unique clinical syndrome characterized by acute bronchoconstriction following the administration of aspirin and/or non-steroidal anti-inflammatory drugs. Objective: We assessed the prevalence and investigated the demographic and clinical characteristics of adult patients with aspirin-intolerant asthma in Korea. Methods: Using an adult asthma cohort (COREA) from 11 university hospitals in Korea, we analyzed the prevalence of aspirin-intolerant asthma, defined as a positive response to the question: "Have you ever experienced dyspnea and cough after taking an aspirin or any NSAID (cold medicine)?" Demographic and clinical characteristics were compared between patients with aspirin-intolerant asthma and aspirin-tolerant asthma. Results: Aspirin-intolerant asthma was reported in 68 (5.8%) of 1173 adult asthmatics (age 15-84). Patients with aspirin-intolerant asthma had a lower mean age (43.9 ± 13.4 vs. 49.0 ± 15.6, P = 0.003) and a higher prevalence of rhinosinusitis (77.9% vs. 61.7%, P = 0.012) and atopic dermatitis (16.2% vs. 5.7%, P = 0.001) than aspirin-tolerant asthma patients. There were no significant differences in lung function, asthma severity or the use of asthma controllers. However, aspirin-intolerant asthma was associated with greater use of healthcare services over a lifetime and over the past 12 months. Aspirin-intolerant asthma was significantly associated with emergency room visits over the past 12 months (P = 0.029, OR 2.19, 95% CI 1.08-4.42). Conclusion: Based on histories, the prevalence of aspirin-intolerant asthma is 5.8% among adult asthma patients in Korea. Aspirin-intolerant asthma is associated with lower age, higher prevalence of rhinosinusitis and atopic dermatitis, and more frequent exacerbations.

Original languageEnglish
Pages (from-to)202-208
Number of pages7
JournalRespiratory Medicine
Issue number2
StatePublished - Feb 2013

Bibliographical note

Funding Information:
This study was supported by a grant from the Korean Health 21 R&D Project, Ministry of Health, Welfare and Family Affairs , Republic of Korea ( A102065 ).


  • Aspirin-intolerant asthma
  • Characteristics
  • Prevalence


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