Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians

Pei Chuan Ho; Wai Haung Yu; Boon Lead Tee; Wan Ping Lee; Clara Li; Yian Gu; Jennifer S. Yokoyama; Dolly Reyes-Dumeyer; Yun Beom Choi; Hyun Sik Yang; Badri N. Vardarajan; Marian Tzuang; Kevin Lieu; Anna Lu; Kelley M. Faber; Zoë D. Potter; Carolyn Revta; Maureen Kirsch; Jake McCallum; Diana Mei; Briana Booth; Laura B. Cantwell; Fangcong Chen; Sephera Chou; Dewi Clark; Michelle Deng; Ting Hei Hong; Ling Jen Hwang; Lilly Jiang; Yoonmee Joo; Younhee Kang; Ellen S. Kim; Hoowon Kim; Kyungmin Kim; Amanda B. Kuzma; Eleanor Lam; Serggio C. Lanata; Kunho Lee; Donghe Li; Mingyao Li; Xiang Li; Chia Lun Liu; Collin Liu; Linghsi Liu; Jody Lynn Lupo; Khai Nguyen; Shannon E. Pfleuger; James Qian; Winnie Qian; Veronica Ramirez; Kristen A. Russ; Eun Hyun Seo; Yeunjoo E. Song; Maria Carmela Tartaglia; Lu Tian; Mina Torres; Namkhue Vo; Ellen C. Wong; Yuan Xie; Eugene B. Yau; Isabelle Yi; Victoria Yu; Xiaoyi Zeng; Peter St George-Hyslop; Rhoda Au; Gerard D. Schellenberg; Jeffrey L. Dage; Rohit Varma; Ging Yuek R. Hsiung; Howard Rosen; Victor W. Henderson; Tatiana Foroud; Walter A. Kukull; Guerry M. Peavy; Haeok Lee; Howard H. Feldman; Richard Mayeux; Helena Chui; Gyungah R. Jun; Van M. Ta Park; Tiffany W. Chow; Li San Wang

doi:10.1002/alz.13611

Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians

Pei Chuan Ho, Wai Haung Yu, Boon Lead Tee, Wan Ping Lee, Clara Li, Yian Gu, Jennifer S. Yokoyama, Dolly Reyes-Dumeyer, Yun Beom Choi, Hyun Sik Yang, Badri N. Vardarajan, Marian Tzuang, Kevin Lieu, Anna Lu, Kelley M. Faber, Zoë D. Potter, Carolyn Revta, Maureen Kirsch, Jake McCallum, Diana MeiBriana Booth, Laura B. Cantwell, Fangcong Chen, Sephera Chou, Dewi Clark, Michelle Deng, Ting Hei Hong, Ling Jen Hwang, Lilly Jiang, Yoonmee Joo, Younhee Kang, Ellen S. Kim, Hoowon Kim, Kyungmin Kim, Amanda B. Kuzma, Eleanor Lam, Serggio C. Lanata, Kunho Lee, Donghe Li, Mingyao Li, Xiang Li, Chia Lun Liu, Collin Liu, Linghsi Liu, Jody Lynn Lupo, Khai Nguyen, Shannon E. Pfleuger, James Qian, Winnie Qian, Veronica Ramirez, Kristen A. Russ, Eun Hyun Seo, Yeunjoo E. Song, Maria Carmela Tartaglia, Lu Tian, Mina Torres, Namkhue Vo, Ellen C. Wong, Yuan Xie, Eugene B. Yau, Isabelle Yi, Victoria Yu, Xiaoyi Zeng, Peter St George-Hyslop, Rhoda Au, Gerard D. Schellenberg, Jeffrey L. Dage, Rohit Varma, Ging Yuek R. Hsiung, Howard Rosen, Victor W. Henderson, Tatiana Foroud, Walter A. Kukull, Guerry M. Peavy, Haeok Lee, Howard H. Feldman, Richard Mayeux, Helena Chui, Gyungah R. Jun, Van M. Ta Park, Tiffany W. Chow, Li San Wang

Division of Nursing

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

INTRODUCTION: Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non-genetic/lifestyle factors impact this multi-ethnic population. METHODS: The ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese. RESULTS: ACAD has recruited 606 participants with an additional 900 expressing interest in enrollment since program inception. DISCUSSION: ACAD's traction indicates the feasibility of recruiting Asians for clinical research to enhance understanding of AD risk factors. ACAD will recruit > 5000 participants to identify genetic and non-genetic/lifestyle AD risk factors, establish blood biomarker levels for AD diagnosis, and facilitate clinical trial readiness. HIGHLIGHTS: The Asian Cohort for Alzheimer's Disease (ACAD) promotes awareness of under-investment in clinical research for Asians. We are recruiting Asian Americans and Canadians for novel insights into Alzheimer's disease. We describe culturally appropriate recruitment strategies and data collection protocol. ACAD addresses challenges of recruitment from heterogeneous Asian subcommunities. We aim to implement a successful recruitment program that enrolls across three Asian subcommunities.

Original language	English
Pages (from-to)	2058-2071
Number of pages	14
Journal	Alzheimer's and Dementia
Volume	20
Issue number	3
DOIs	https://doi.org/10.1002/alz.13611
State	Published - Mar 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

Keywords

Alzheimer's disease
Asian
biosamples
community-based participatory research
dementia
environmental
genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/alz.13611

Cite this

Ho, P. C., Yu, W. H., Tee, B. L., Lee, W. P., Li, C., Gu, Y., Yokoyama, J. S., Reyes-Dumeyer, D., Choi, Y. B., Yang, H. S., Vardarajan, B. N., Tzuang, M., Lieu, K., Lu, A., Faber, K. M., Potter, Z. D., Revta, C., Kirsch, M., McCallum, J., ... Wang, L. S. (2024). Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians. Alzheimer's and Dementia, 20(3), 2058-2071. https://doi.org/10.1002/alz.13611

@article{56c1425d0e074dca8de5c1336d2e5745,

title = "Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians",

abstract = "INTRODUCTION: Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non-genetic/lifestyle factors impact this multi-ethnic population. METHODS: The ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese. RESULTS: ACAD has recruited 606 participants with an additional 900 expressing interest in enrollment since program inception. DISCUSSION: ACAD's traction indicates the feasibility of recruiting Asians for clinical research to enhance understanding of AD risk factors. ACAD will recruit > 5000 participants to identify genetic and non-genetic/lifestyle AD risk factors, establish blood biomarker levels for AD diagnosis, and facilitate clinical trial readiness. HIGHLIGHTS: The Asian Cohort for Alzheimer's Disease (ACAD) promotes awareness of under-investment in clinical research for Asians. We are recruiting Asian Americans and Canadians for novel insights into Alzheimer's disease. We describe culturally appropriate recruitment strategies and data collection protocol. ACAD addresses challenges of recruitment from heterogeneous Asian subcommunities. We aim to implement a successful recruitment program that enrolls across three Asian subcommunities.",

keywords = "Alzheimer's disease, Asian, biosamples, community-based participatory research, dementia, environmental, genetics",

author = "Ho, {Pei Chuan} and Yu, {Wai Haung} and Tee, {Boon Lead} and Lee, {Wan Ping} and Clara Li and Yian Gu and Yokoyama, {Jennifer S.} and Dolly Reyes-Dumeyer and Choi, {Yun Beom} and Yang, {Hyun Sik} and Vardarajan, {Badri N.} and Marian Tzuang and Kevin Lieu and Anna Lu and Faber, {Kelley M.} and Potter, {Zo{\"e} D.} and Carolyn Revta and Maureen Kirsch and Jake McCallum and Diana Mei and Briana Booth and Cantwell, {Laura B.} and Fangcong Chen and Sephera Chou and Dewi Clark and Michelle Deng and Hong, {Ting Hei} and Hwang, {Ling Jen} and Lilly Jiang and Yoonmee Joo and Younhee Kang and Kim, {Ellen S.} and Hoowon Kim and Kyungmin Kim and Kuzma, {Amanda B.} and Eleanor Lam and Lanata, {Serggio C.} and Kunho Lee and Donghe Li and Mingyao Li and Xiang Li and Liu, {Chia Lun} and Collin Liu and Linghsi Liu and Lupo, {Jody Lynn} and Khai Nguyen and Pfleuger, {Shannon E.} and James Qian and Winnie Qian and Veronica Ramirez and Russ, {Kristen A.} and Seo, {Eun Hyun} and Song, {Yeunjoo E.} and Tartaglia, {Maria Carmela} and Lu Tian and Mina Torres and Namkhue Vo and Wong, {Ellen C.} and Yuan Xie and Yau, {Eugene B.} and Isabelle Yi and Victoria Yu and Xiaoyi Zeng and {St George-Hyslop}, Peter and Rhoda Au and Schellenberg, {Gerard D.} and Dage, {Jeffrey L.} and Rohit Varma and Hsiung, {Ging Yuek R.} and Howard Rosen and Henderson, {Victor W.} and Tatiana Foroud and Kukull, {Walter A.} and Peavy, {Guerry M.} and Haeok Lee and Feldman, {Howard H.} and Richard Mayeux and Helena Chui and Jun, {Gyungah R.} and {Ta Park}, {Van M.} and Chow, {Tiffany W.} and Wang, {Li San}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2024",

month = mar,

doi = "10.1002/alz.13611",

language = "English",

volume = "20",

pages = "2058--2071",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley & Sons Inc.",

number = "3",

}

Ho, PC, Yu, WH, Tee, BL, Lee, WP, Li, C, Gu, Y, Yokoyama, JS, Reyes-Dumeyer, D, Choi, YB, Yang, HS, Vardarajan, BN, Tzuang, M, Lieu, K, Lu, A, Faber, KM, Potter, ZD, Revta, C, Kirsch, M, McCallum, J, Mei, D, Booth, B, Cantwell, LB, Chen, F, Chou, S, Clark, D, Deng, M, Hong, TH, Hwang, LJ, Jiang, L, Joo, Y, Kang, Y, Kim, ES, Kim, H, Kim, K, Kuzma, AB, Lam, E, Lanata, SC, Lee, K, Li, D, Li, M, Li, X, Liu, CL, Liu, C, Liu, L, Lupo, JL, Nguyen, K, Pfleuger, SE, Qian, J, Qian, W, Ramirez, V, Russ, KA, Seo, EH, Song, YE, Tartaglia, MC, Tian, L, Torres, M, Vo, N, Wong, EC, Xie, Y, Yau, EB, Yi, I, Yu, V, Zeng, X, St George-Hyslop, P, Au, R, Schellenberg, GD, Dage, JL, Varma, R, Hsiung, GYR, Rosen, H, Henderson, VW, Foroud, T, Kukull, WA, Peavy, GM, Lee, H, Feldman, HH, Mayeux, R, Chui, H, Jun, GR, Ta Park, VM, Chow, TW & Wang, LS 2024, 'Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians', Alzheimer's and Dementia, vol. 20, no. 3, pp. 2058-2071. https://doi.org/10.1002/alz.13611

TY - JOUR

T1 - Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians

AU - Ho, Pei Chuan

AU - Yu, Wai Haung

AU - Tee, Boon Lead

AU - Lee, Wan Ping

AU - Li, Clara

AU - Gu, Yian

AU - Yokoyama, Jennifer S.

AU - Reyes-Dumeyer, Dolly

AU - Choi, Yun Beom

AU - Yang, Hyun Sik

AU - Vardarajan, Badri N.

AU - Tzuang, Marian

AU - Lieu, Kevin

AU - Lu, Anna

AU - Faber, Kelley M.

AU - Potter, Zoë D.

AU - Revta, Carolyn

AU - Kirsch, Maureen

AU - McCallum, Jake

AU - Mei, Diana

AU - Booth, Briana

AU - Cantwell, Laura B.

AU - Chen, Fangcong

AU - Chou, Sephera

AU - Clark, Dewi

AU - Deng, Michelle

AU - Hong, Ting Hei

AU - Hwang, Ling Jen

AU - Jiang, Lilly

AU - Joo, Yoonmee

AU - Kang, Younhee

AU - Kim, Ellen S.

AU - Kim, Hoowon

AU - Kim, Kyungmin

AU - Kuzma, Amanda B.

AU - Lam, Eleanor

AU - Lanata, Serggio C.

AU - Lee, Kunho

AU - Li, Donghe

AU - Li, Mingyao

AU - Li, Xiang

AU - Liu, Chia Lun

AU - Liu, Collin

AU - Liu, Linghsi

AU - Lupo, Jody Lynn

AU - Nguyen, Khai

AU - Pfleuger, Shannon E.

AU - Qian, James

AU - Qian, Winnie

AU - Ramirez, Veronica

AU - Russ, Kristen A.

AU - Seo, Eun Hyun

AU - Song, Yeunjoo E.

AU - Tartaglia, Maria Carmela

AU - Tian, Lu

AU - Torres, Mina

AU - Vo, Namkhue

AU - Wong, Ellen C.

AU - Xie, Yuan

AU - Yau, Eugene B.

AU - Yi, Isabelle

AU - Yu, Victoria

AU - Zeng, Xiaoyi

AU - St George-Hyslop, Peter

AU - Au, Rhoda

AU - Schellenberg, Gerard D.

AU - Dage, Jeffrey L.

AU - Varma, Rohit

AU - Hsiung, Ging Yuek R.

AU - Rosen, Howard

AU - Henderson, Victor W.

AU - Foroud, Tatiana

AU - Kukull, Walter A.

AU - Peavy, Guerry M.

AU - Lee, Haeok

AU - Feldman, Howard H.

AU - Mayeux, Richard

AU - Chui, Helena

AU - Jun, Gyungah R.

AU - Ta Park, Van M.

AU - Chow, Tiffany W.

AU - Wang, Li San

PY - 2024/3

Y1 - 2024/3

N2 - INTRODUCTION: Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non-genetic/lifestyle factors impact this multi-ethnic population. METHODS: The ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese. RESULTS: ACAD has recruited 606 participants with an additional 900 expressing interest in enrollment since program inception. DISCUSSION: ACAD's traction indicates the feasibility of recruiting Asians for clinical research to enhance understanding of AD risk factors. ACAD will recruit > 5000 participants to identify genetic and non-genetic/lifestyle AD risk factors, establish blood biomarker levels for AD diagnosis, and facilitate clinical trial readiness. HIGHLIGHTS: The Asian Cohort for Alzheimer's Disease (ACAD) promotes awareness of under-investment in clinical research for Asians. We are recruiting Asian Americans and Canadians for novel insights into Alzheimer's disease. We describe culturally appropriate recruitment strategies and data collection protocol. ACAD addresses challenges of recruitment from heterogeneous Asian subcommunities. We aim to implement a successful recruitment program that enrolls across three Asian subcommunities.

AB - INTRODUCTION: Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non-genetic/lifestyle factors impact this multi-ethnic population. METHODS: The ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese. RESULTS: ACAD has recruited 606 participants with an additional 900 expressing interest in enrollment since program inception. DISCUSSION: ACAD's traction indicates the feasibility of recruiting Asians for clinical research to enhance understanding of AD risk factors. ACAD will recruit > 5000 participants to identify genetic and non-genetic/lifestyle AD risk factors, establish blood biomarker levels for AD diagnosis, and facilitate clinical trial readiness. HIGHLIGHTS: The Asian Cohort for Alzheimer's Disease (ACAD) promotes awareness of under-investment in clinical research for Asians. We are recruiting Asian Americans and Canadians for novel insights into Alzheimer's disease. We describe culturally appropriate recruitment strategies and data collection protocol. ACAD addresses challenges of recruitment from heterogeneous Asian subcommunities. We aim to implement a successful recruitment program that enrolls across three Asian subcommunities.

KW - Alzheimer's disease

KW - Asian

KW - biosamples

KW - community-based participatory research

KW - dementia

KW - environmental

KW - genetics

UR - http://www.scopus.com/inward/record.url?scp=85182150023&partnerID=8YFLogxK

U2 - 10.1002/alz.13611

DO - 10.1002/alz.13611

M3 - Article

C2 - 38215053

AN - SCOPUS:85182150023

SN - 1552-5260

VL - 20

SP - 2058

EP - 2071

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 3

ER -

Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians

Abstract

Bibliographical note

Keywords

UN SDGs

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