Approaches for novel enzyme discovery from marine environments

Hyun Sook Lee, Kae Kyoung Kwon, Sung Gyun Kang, Sun Shin Cha, Sang Jin Kim, Jung Hyun Lee

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


The enormous pool of biodiversity in marine ecosystems is an excellent natural reservoir for acquiring an inventory of enzymes with potential for biotechnological applications. Moreover, the opportunity for sustainable resource management has been greatly enhanced by recent advances in culturing methods for recalcitrant microbes. In this review, we will focus primarily on successful examples in culturing marine microbes and provide an overview of work examining the biotechnological potential of the marine reservoir, mainly through genomic strategies, such as activity-based functional screening of genomic and metagenomic libraries and homology-driven screening of enormous amounts of sequence data.

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalCurrent Opinion in Biotechnology
Issue number3
StatePublished - Jun 2010

Bibliographical note

Funding Information:
This work was supported by the KORDI in-house program (PE98513) , and the Marine and Extreme Genome Research Center program and the Development of Biohydrogen Production Technology Using Hyperthermophilic Archaea program of the Ministry of Land, Transport, and Maritime Affairs , Republic of Korea.


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