Application of Tonsil-Derived Mesenchymal Stem Cells in Tissue Regeneration: Concise Review

Se Young Oh, Young Min Choi, Ha Yeong Kim, Yoon Shin Park, Sung Chul Jung, Joo Won Park, So Youn Woo, Kyung Ha Ryu, Han Su Kim, Inho Jo

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Since the discovery of stem cells and multipotency characteristics of mesenchymal stem cells (MSCs), there has been tremendous development in regenerative medicine. MSCs derived from bone marrow have been widely used in various research applications, yet there are limitations such as invasiveness of obtaining samples, low yield and proliferation rate, and questions regarding their practicality in clinical applications. Some have suggested that MSCs from other sources, specifically those derived from palatine tonsil tissues, that is, tonsil-derived MSCs (TMSCs), could be considered as a new potential therapeutic tool in regenerative medicine due to their superior proliferation rate and differentiation capabilities with low immunogenicity and ease of obtaining. Several studies have determined that TMSCs have differentiation potential not only into the mesodermal lineage but also into the endodermal as well as ectodermal lineages, expanding their potential usage and placing them as an appealing option to consider for future studies in regenerative medicine. In this review, the differentiation capacities of TMSCs and their therapeutic competencies from past studies are addressed. Stem Cells 2019;37:1252–1260.

Original languageEnglish
Pages (from-to)1252-1260
Number of pages9
JournalStem Cells
Issue number10
StatePublished - 1 Oct 2019

Bibliographical note

Publisher Copyright:
©2019 The Authors. Stem Cells published by Wiley Periodicals, Inc. on behalf of AlphaMed Press 2019


  • Differentiation
  • Immunomodulation
  • Mesenchymal stem cells
  • Regenerative medicine
  • Tissue engineering


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