Application of Monodirectional Janus Patch to Oromucosal Delivery System

Jae Bem You, Ah Young Choi, Jieung Baek, Myung Seok Oh, Sung Gap Im, Kyung Eun Lee, Hye Sun Gwak

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Drug delivery through mucosae has received huge research attention owing to its advantageous characteristics such as accurate dose control and the avoidance of premature metabolism of vulnerable drugs by oral administration. However, body fluid in mucosae may dissolve the drug, releasing it to unwanted directions. Here, a Janus drug delivery patch with monodirectional diffusion property is devised to deliver drugs efficiently and to overcome the issue of unwanted drug release. A polyester fabric is coated with a hydrophobic polymer, poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-heptadecafluorodecyl methacrylate), via initiated chemical vapor deposition. Subsequently, hydrophilicity is rendered selectively on one surface by base-catalyzed hydrolysis to obtain a Janus substrate with both hydrophobic and hydrophilic surfaces. The hydrophilic surface of the Janus substrate is further coated with resveratrol-loaded hydrogel to produce a Janus drug delivery patch. The fabricated patch efficiently blocks fluid penetration from one side to the other in mucous environment. Delivery of resveratrol through hairless mouse skin and reconstructed human mucosae using Janus patch shows higher permeation flux compared to bare control patch. The Janus drug delivery patch shown in this study can be a useful tool for efficient transmucosal delivery of various kinds of drugs.

Original languageEnglish
Pages (from-to)2229-2236
Number of pages8
JournalAdvanced Healthcare Materials
Volume4
Issue number15
DOIs
StatePublished - 28 Oct 2015

Keywords

  • Drug delivery
  • Initiated chemical vapor deposition (iCVD)
  • Janus patch
  • Monodirectional
  • Oromucosa

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