Application of Magnetic Resonance Spectroscopic Imaging to Addiction Research

Sujung Yoon, In Kyoon Lyoo, Perry F. Renshaw

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations


This chapter focuses on application of magnetic resonance spectroscopy (MRS) methodologies and their relevance to drug addiction research. It introduces the significant features and characteristics of currently available MRS techniques and summarizes empirical findings. It outlines limitations of current MRS approaches and highlights potential future research directions to provide an enhanced understanding of brain mechanisms that underlie addiction. Functional and structural alterations observed in neuroimaging studies support conclusion that chronic exposure to alcohol results in neurotoxic effects on brain. The chapter reviews a number of MRS studies for neurometabolite quantification and localization in each patient group dependent on different classes of substance. Ongoing and future studies to expand the use of MRS findings as a potential surrogate biomarker have unique clinical benefits. This edition first published 2013

Original languageEnglish
Title of host publicationThe Wiley-Blackwell Handbook of Addiction Psychopharmacology
PublisherWiley Blackwell
Number of pages44
ISBN (Print)9781119978268
StatePublished - 15 Jan 2013


  • Brain damage
  • Drug addiction research
  • Magnetic resonance spectroscopic imaging (MRSI)
  • Magnetic resonance spectroscopy (MRS) methodology
  • Neurotoxic effects


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