Applicability of non-halogenated methyl propionate to microencapsulation

Jukyung Kang, Edel Sah, Hongkee Sah

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Applicability of methyl propionate to microencapsulation was evaluated with regard to volatility, capability of forming emulsions, and their quality. An emulsion-based technique was then developed to encapsulate progesterone into poly-d,l-lactide-co-glycolide microspheres. Their characteristics were compared with those prepared using ethyl acetate. Our results demonstrated that methyl propionate had greater evaporative tendency and less water miscibility than ethyl acetate did. The former allowed us to prepare good microspheres. Their average volume mean diameter was 68.3 ± 1.7 μm with a span index of 0.91 ± 0.13. Progesterone did not undergo polymorphic transition during microencapsulation, and its encapsulation efficiency ranged from 41.80 ± 1.83 to 85.64 ± 1.95%. Residual methyl propionate in various microspheres was found to be 0.97 ± 0.03 to 1.54 ± 0.07%. Such microsphere characteristics were quite similar to those prepared by the ethyl acetate-based microencapsulation process. Overall, our findings reflect that methyl propionate has a potential to become an invaluable solvent for microencapsulation.

Original languageEnglish
Pages (from-to)323-332
Number of pages10
JournalJournal of Microencapsulation
Issue number4
StatePublished - 2014

Bibliographical note

Funding Information:
This study was supported by a grant from the Korean Health Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A092018). The authors report no declaration of interest. The authors alone are responsible for the content and writing of the article.


  • Injectable dosage form
  • Methyl propionate
  • Non-halogenated solvents
  • Poly-d,l-lactide-co-glycolide


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