Apoptotic response of ovarian cancer cells in hypoxic conditions

Claus R. Poulsen; Bryan Lincoln; Ivan Dimov; Jose L. Garcia-Cordero; Sharon O'Toole; Marek Radomski; John O'Leary; Luke P. Lee

Apoptotic response of ovarian cancer cells in hypoxic conditions

Claus R. Poulsen, Bryan Lincoln, Ivan Dimov, Jose L. Garcia-Cordero, Sharon O'Toole, Marek Radomski, John O'Leary, Luke P. Lee

Department of Chemistry & Nanoscience

Research output: Contribution to conference › Paper › peer-review

1 Scopus citations

Abstract

A cell culture device is presented that has a daily consumption of only 20 μl media. The device is used for testing the response of ovarian cancer cells to the chemotherapy drug Paclitaxel at hypoxic conditions. In hypoxic conditions, the mortality is increased 3.2 times at 34 μg/ml Paclitaxel. However, this might not be due to apoptosis as the mitochondria activity and nuclei size is unchanged compared to in the absence of Paclitaxel.

Original language	English
Pages	1864-1866
Number of pages	3
State	Published - 2008
Event	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States Duration: 12 Oct 2008 → 16 Oct 2008

Conference

Conference	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
Country/Territory	United States
City	San Diego, CA
Period	12/10/08 → 16/10/08

Keywords

Apoptosis
Cell culture
Chemotherapeutic drug
Hypoxia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Apoptotic response of ovarian cancer cells in hypoxic conditions",

abstract = "A cell culture device is presented that has a daily consumption of only 20 μl media. The device is used for testing the response of ovarian cancer cells to the chemotherapy drug Paclitaxel at hypoxic conditions. In hypoxic conditions, the mortality is increased 3.2 times at 34 μg/ml Paclitaxel. However, this might not be due to apoptosis as the mitochondria activity and nuclei size is unchanged compared to in the absence of Paclitaxel.",

keywords = "Apoptosis, Cell culture, Chemotherapeutic drug, Hypoxia",

author = "Poulsen, {Claus R.} and Bryan Lincoln and Ivan Dimov and Garcia-Cordero, {Jose L.} and Sharon O'Toole and Marek Radomski and John O'Leary and Lee, {Luke P.}",

year = "2008",

language = "English",

pages = "1864--1866",

note = "12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 ; Conference date: 12-10-2008 Through 16-10-2008",

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TY - CONF

T1 - Apoptotic response of ovarian cancer cells in hypoxic conditions

AU - Poulsen, Claus R.

AU - Lincoln, Bryan

AU - Dimov, Ivan

AU - Garcia-Cordero, Jose L.

AU - O'Toole, Sharon

AU - Radomski, Marek

AU - O'Leary, John

AU - Lee, Luke P.

PY - 2008

Y1 - 2008

N2 - A cell culture device is presented that has a daily consumption of only 20 μl media. The device is used for testing the response of ovarian cancer cells to the chemotherapy drug Paclitaxel at hypoxic conditions. In hypoxic conditions, the mortality is increased 3.2 times at 34 μg/ml Paclitaxel. However, this might not be due to apoptosis as the mitochondria activity and nuclei size is unchanged compared to in the absence of Paclitaxel.

AB - A cell culture device is presented that has a daily consumption of only 20 μl media. The device is used for testing the response of ovarian cancer cells to the chemotherapy drug Paclitaxel at hypoxic conditions. In hypoxic conditions, the mortality is increased 3.2 times at 34 μg/ml Paclitaxel. However, this might not be due to apoptosis as the mitochondria activity and nuclei size is unchanged compared to in the absence of Paclitaxel.

KW - Apoptosis

KW - Cell culture

KW - Chemotherapeutic drug

KW - Hypoxia

UR - http://www.scopus.com/inward/record.url?scp=84902532377&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:84902532377

SP - 1864

EP - 1866

T2 - 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008

Y2 - 12 October 2008 through 16 October 2008

ER -

Apoptotic response of ovarian cancer cells in hypoxic conditions

Abstract

Conference

Keywords

UN SDGs

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