Anxiety and depression in probable migraine: A population-based study

Tae Jin Song, Soo Jin Cho, Won Joo Kim, Kwang Ik Yang, Chang Ho Yun, Min Kyung Chu

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Background Although probable migraine (PM) is common among headache sufferers, there is little knowledge of the prevalence and impacts of comorbid anxiety and depression in patients with PM. We assessed the prevalence and impact of anxiety and depression among PM sufferers in the general population. Methods We recruited Korean individuals aged 19-69 years via stratified random sampling and assessed headache type, anxiety, and depression among them using structured interviews. Results In a representative sample of 2695 individuals, 143 (5.3%) and 379 (14.1%) had migraine and PM, respectively. Fewer patients with PM had anxiety (17.7% vs. 30.1%, p = 0.002) and depression (8.7% vs. 16.8%, p = 0.007) compared to those with migraine. Prevalence of anxiety and depression was lower in people with PM than in those with migraine in univariable analysis, but insignificant after including headache intensity and headache frequency for adjustment. Headache frequency, headache intensity, and impact of headache were significantly higher among PM and migraine patients with anxiety and depression than among those without. Conclusions The prevalence of anxiety and depression was lower among individuals with PM compared to those with migraine. However, they were still prevalent and associated with an exacerbation of symptoms among individuals with PM.

Original languageEnglish
Pages (from-to)845-854
Number of pages10
Issue number9
StatePublished - 1 Aug 2017

Bibliographical note

Publisher Copyright:
© 2016 International Headache Society.


  • Anxiety
  • depression
  • headache
  • migraine
  • probable migraine


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