Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells

Eun Joung Ki, Dae Kee Kim, Yhun Yhong Sheen

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Histone deacetylase inhibitors are new class of chemotherapeutic drugs able to induce tumor cell apoptosis and/or cell cycle arrest. Trichostatin A, an antifungal antibiotic, and HC-toxin are potent and specific inhibitors of histone deacetylase activity. In this study, we have examined the antiproliferative activities of trichostatin A and HC-toxin in estrogen receptor positive human breast cancer, T47D cells. Both trichostatin A and HC-toxin showed potent antiproliferative efficacy and cell cycle arrest at G inf2/inf/M in T47D human breast cancer cells in a dose-dependent manner. Trichostatin A caused potent apoptosis of T47D human breast cancer cells and trichostatin A-induced apoptosis might be involved in an increase of caspase-3/7 activity. HC-toxin evoked apoptosis of T47D cells and HC-toxin induced apoptosis might not be mediated through direct increase in caspase-3/7 activity. We have identified potent activities of antiproliferation, apoptosis, and cell cycle arrest of trichostatin A and HC-toxin in estrogen receptor positive human breast cancer cell line T47D.

Original languageEnglish
Pages (from-to)640-645
Number of pages6
JournalArchives of Pharmacal Research
Volume27
Issue number6
DOIs
StatePublished - 30 Jun 2004

Keywords

  • HC-toxin
  • Histone deacetylase
  • T47D cell
  • Trichostatin A

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