Abstract
Histone deacetylase inhibitors are new class of chemotherapeutic drugs able to induce tumor cell apoptosis and/or cell cycle arrest. Trichostatin A, an antifungal antibiotic, and HC-toxin are potent and specific inhibitors of histone deacetylase activity. In this study, we have examined the antiproliferative activities of trichostatin A and HC-toxin in estrogen receptor positive human breast cancer, T47D cells. Both trichostatin A and HC-toxin showed potent antiproliferative efficacy and cell cycle arrest at G inf2/inf/M in T47D human breast cancer cells in a dose-dependent manner. Trichostatin A caused potent apoptosis of T47D human breast cancer cells and trichostatin A-induced apoptosis might be involved in an increase of caspase-3/7 activity. HC-toxin evoked apoptosis of T47D cells and HC-toxin induced apoptosis might not be mediated through direct increase in caspase-3/7 activity. We have identified potent activities of antiproliferation, apoptosis, and cell cycle arrest of trichostatin A and HC-toxin in estrogen receptor positive human breast cancer cell line T47D.
| Original language | English |
|---|---|
| Pages (from-to) | 640-645 |
| Number of pages | 6 |
| Journal | Archives of Pharmacal Research |
| Volume | 27 |
| Issue number | 6 |
| DOIs | |
| State | Published - 30 Jun 2004 |
Bibliographical note
Funding Information:This research was supported by the grant NTP 250 from the KFDA of Korea.
Keywords
- HC-toxin
- Histone deacetylase
- T47D cell
- Trichostatin A
