Antimicrobial resistance in community-acquired urinary tract infections: Results from the Korean Antimicrobial Resistance Monitoring System

Seung Ju Lee; Dong Sup Lee; Hyun Sop Choe; Bong Suk Shim; Chul Sung Kim; Min Eui Kim; Yong Hyun Cho

doi:10.1007/s10156-010-0178-x

Antimicrobial resistance in community-acquired urinary tract infections: Results from the Korean Antimicrobial Resistance Monitoring System

Seung Ju Lee, Dong Sup Lee, Hyun Sop Choe, Bong Suk Shim, Chul Sung Kim, Min Eui Kim, Yong Hyun Cho

Department of Urology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The Korean Antimicrobial Resistance Monitoring System was established and the first nationwide surveillance of bacterial uropathogens was conducted during the period from January 2008 to June 2009. With the cooperation of 34 medical centers throughout South Korea, a total of 1994 strains belonging to clinically relevant bacterial uropathogens were collected from patients with community-acquired urinary tract infections (UTIs). To compare with past data, understand a trend of antimicrobial resistance, and ultimately determine new regimens for empirical treatment of uncomplicated cystitis, the antimicrobial susceptibilities against Escherichia coli in uncomplicated cystitis to commonly prescribed drugs were investigated. In uncomplicated cystitis, the most prevalent causative organism was E. coli (72.7%), followed by Enterococcus faecalis (10.7%) and Klebsiella pneumoniae (3.5%). Among E. coli isolates from acute uncomplicated cystitis, 38.5% were susceptible to ampicillin, 80.7% to amoxicillin/clavulanate, 67.3% to trimethoprim/sulfamethoxazole, 74.6% to ciprofloxacin, 77.5% to levofloxacin, 86.0% to cefazolin, 86.1% to cefuroxime, 93.6% to cefpodoxime, 94.7% to ceftriaxone, 99.5% to amikacin, 80.9% to tobramycin, and 76.6% to gentamicin. An increasing tendency of resistance to ciprofloxacin (24.8%) has been observed compared with the similar studies in 2006 (23.4%) and 2002 (15.2%) from patients with uncomplicated cystitis. These data provide much needed information on the prevalence of antimicrobial resistance in community-acquired UTIs in South Korea and will be a useful reference for future periodic surveillance studies.

Original language	English
Pages (from-to)	440-446
Number of pages	7
Journal	Journal of Infection and Chemotherapy
Volume	17
Issue number	3
DOIs	https://doi.org/10.1007/s10156-010-0178-x
State	Published - Jun 2011

Bibliographical note

Funding Information:
Urology Clinic, Seoul); Chang Hee Han and Hyun Rim Lee (The Catholic University of Korea, Uijeongbu St. Mary’s Hospital, Uijeongbu); Su Yeon Cho (The Catholic University of Korea, St. Paul’s Hospital, Seoul); Byung Hee Lee (The Catholic University of Korea, Yeouido St. Mary’s Hospital, Seoul); Nam Suk Lee (The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul); Je Mo Yoo (The Catholic University of Korea, Bucheon St. Mary’s Hospital, Bucheon); Moo Youl Jeong (The Catholic University of Korea, College of Medicine, St. Vincent’s Hospital, Suwon); Sang Don Lee (Pusan National University, Busan); Dong Hoon Lim (Chosun University, Gwangju); In Rae Cho (Inje University, Ilsan Paik Hospital, Ilsan); Gil Ho Lee (Dankook University, Cheonan); Yong Gil Na (Chungnam National University, Daejeon); Kyung Hwangbo (Green Hospital, Seoul); Byung Ha Chung (Yonsei University Medical School, Gangnam Severance Haspital, Seoul); Tae Hyoung Kim (Chung Ang University, Yongsan, Seoul); In Hoo Chang (Chung Ang University, Seoul); Byong Ha In (Hongik Has-pital, Seoul); Seung Ki Min (National Police Hospital, Seoul); Sang Eun Lee (Seoul National University, Bundang); Duk Yoon Kim (Catholic University of Daegu, Daegu); Kee Uk Chung (Ansan Thema Clinic, Ansan); In Chul Seon (Osan Hankook Hospital, Osan); Seong Woon Park (Gwangju Christian Hospital, Gwangju); Jung Seon Lee (Good Morning Urology Clinic, Mokpo); Seung Il Jung (Chonnam National University, Gwangju); Soo Dong Kim (Dong-A University, Busan); Kook Hyeong Hwang (HwangKookHyeong Urology Clinic, Busan); Chol Jong Back (Good Morning Urology Clinic, Daejeon); Sue Yong Sung (Su Hospital, Munmak); Woong Gyo Jung (JungWoongGyo Urology Clinic, Wonju); Seong Ho Lee (Hallym University Chuncheon Sacred Heart, Chuncheon); and Jung Sik Huh (Jeju National University, Jeju). This study was supported and funded by Korea Centers for Disease Control and Prevention, Seoul, Korea. This study was approved by a central ethical committee (Catholic Medical Centre, The Catholic University of Korea College of Medicine, Seoul, Korea, No. XCMC08OT015S) and then by the respective local ethical committees.

Keywords

Antimicrobial resistance
Communityacquired infection
Fluoroquinolone
Urinary tract infection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10156-010-0178-x

Cite this

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title = "Antimicrobial resistance in community-acquired urinary tract infections: Results from the Korean Antimicrobial Resistance Monitoring System",

abstract = "The Korean Antimicrobial Resistance Monitoring System was established and the first nationwide surveillance of bacterial uropathogens was conducted during the period from January 2008 to June 2009. With the cooperation of 34 medical centers throughout South Korea, a total of 1994 strains belonging to clinically relevant bacterial uropathogens were collected from patients with community-acquired urinary tract infections (UTIs). To compare with past data, understand a trend of antimicrobial resistance, and ultimately determine new regimens for empirical treatment of uncomplicated cystitis, the antimicrobial susceptibilities against Escherichia coli in uncomplicated cystitis to commonly prescribed drugs were investigated. In uncomplicated cystitis, the most prevalent causative organism was E. coli (72.7%), followed by Enterococcus faecalis (10.7%) and Klebsiella pneumoniae (3.5%). Among E. coli isolates from acute uncomplicated cystitis, 38.5% were susceptible to ampicillin, 80.7% to amoxicillin/clavulanate, 67.3% to trimethoprim/sulfamethoxazole, 74.6% to ciprofloxacin, 77.5% to levofloxacin, 86.0% to cefazolin, 86.1% to cefuroxime, 93.6% to cefpodoxime, 94.7% to ceftriaxone, 99.5% to amikacin, 80.9% to tobramycin, and 76.6% to gentamicin. An increasing tendency of resistance to ciprofloxacin (24.8%) has been observed compared with the similar studies in 2006 (23.4%) and 2002 (15.2%) from patients with uncomplicated cystitis. These data provide much needed information on the prevalence of antimicrobial resistance in community-acquired UTIs in South Korea and will be a useful reference for future periodic surveillance studies.",

keywords = "Antimicrobial resistance, Communityacquired infection, Fluoroquinolone, Urinary tract infection",

author = "Lee, {Seung Ju} and Lee, {Dong Sup} and Choe, {Hyun Sop} and Shim, {Bong Suk} and Kim, {Chul Sung} and Kim, {Min Eui} and Cho, {Yong Hyun}",

note = "Funding Information: Urology Clinic, Seoul); Chang Hee Han and Hyun Rim Lee (The Catholic University of Korea, Uijeongbu St. Mary{\textquoteright}s Hospital, Uijeongbu); Su Yeon Cho (The Catholic University of Korea, St. Paul{\textquoteright}s Hospital, Seoul); Byung Hee Lee (The Catholic University of Korea, Yeouido St. Mary{\textquoteright}s Hospital, Seoul); Nam Suk Lee (The Catholic University of Korea, Seoul St. Mary{\textquoteright}s Hospital, Seoul); Je Mo Yoo (The Catholic University of Korea, Bucheon St. Mary{\textquoteright}s Hospital, Bucheon); Moo Youl Jeong (The Catholic University of Korea, College of Medicine, St. Vincent{\textquoteright}s Hospital, Suwon); Sang Don Lee (Pusan National University, Busan); Dong Hoon Lim (Chosun University, Gwangju); In Rae Cho (Inje University, Ilsan Paik Hospital, Ilsan); Gil Ho Lee (Dankook University, Cheonan); Yong Gil Na (Chungnam National University, Daejeon); Kyung Hwangbo (Green Hospital, Seoul); Byung Ha Chung (Yonsei University Medical School, Gangnam Severance Haspital, Seoul); Tae Hyoung Kim (Chung Ang University, Yongsan, Seoul); In Hoo Chang (Chung Ang University, Seoul); Byong Ha In (Hongik Has-pital, Seoul); Seung Ki Min (National Police Hospital, Seoul); Sang Eun Lee (Seoul National University, Bundang); Duk Yoon Kim (Catholic University of Daegu, Daegu); Kee Uk Chung (Ansan Thema Clinic, Ansan); In Chul Seon (Osan Hankook Hospital, Osan); Seong Woon Park (Gwangju Christian Hospital, Gwangju); Jung Seon Lee (Good Morning Urology Clinic, Mokpo); Seung Il Jung (Chonnam National University, Gwangju); Soo Dong Kim (Dong-A University, Busan); Kook Hyeong Hwang (HwangKookHyeong Urology Clinic, Busan); Chol Jong Back (Good Morning Urology Clinic, Daejeon); Sue Yong Sung (Su Hospital, Munmak); Woong Gyo Jung (JungWoongGyo Urology Clinic, Wonju); Seong Ho Lee (Hallym University Chuncheon Sacred Heart, Chuncheon); and Jung Sik Huh (Jeju National University, Jeju). This study was supported and funded by Korea Centers for Disease Control and Prevention, Seoul, Korea. This study was approved by a central ethical committee (Catholic Medical Centre, The Catholic University of Korea College of Medicine, Seoul, Korea, No. XCMC08OT015S) and then by the respective local ethical committees.",

year = "2011",

month = jun,

doi = "10.1007/s10156-010-0178-x",

language = "English",

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AU - Lee, Dong Sup

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AU - Shim, Bong Suk

AU - Kim, Chul Sung

AU - Kim, Min Eui

AU - Cho, Yong Hyun

N1 - Funding Information: Urology Clinic, Seoul); Chang Hee Han and Hyun Rim Lee (The Catholic University of Korea, Uijeongbu St. Mary’s Hospital, Uijeongbu); Su Yeon Cho (The Catholic University of Korea, St. Paul’s Hospital, Seoul); Byung Hee Lee (The Catholic University of Korea, Yeouido St. Mary’s Hospital, Seoul); Nam Suk Lee (The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul); Je Mo Yoo (The Catholic University of Korea, Bucheon St. Mary’s Hospital, Bucheon); Moo Youl Jeong (The Catholic University of Korea, College of Medicine, St. Vincent’s Hospital, Suwon); Sang Don Lee (Pusan National University, Busan); Dong Hoon Lim (Chosun University, Gwangju); In Rae Cho (Inje University, Ilsan Paik Hospital, Ilsan); Gil Ho Lee (Dankook University, Cheonan); Yong Gil Na (Chungnam National University, Daejeon); Kyung Hwangbo (Green Hospital, Seoul); Byung Ha Chung (Yonsei University Medical School, Gangnam Severance Haspital, Seoul); Tae Hyoung Kim (Chung Ang University, Yongsan, Seoul); In Hoo Chang (Chung Ang University, Seoul); Byong Ha In (Hongik Has-pital, Seoul); Seung Ki Min (National Police Hospital, Seoul); Sang Eun Lee (Seoul National University, Bundang); Duk Yoon Kim (Catholic University of Daegu, Daegu); Kee Uk Chung (Ansan Thema Clinic, Ansan); In Chul Seon (Osan Hankook Hospital, Osan); Seong Woon Park (Gwangju Christian Hospital, Gwangju); Jung Seon Lee (Good Morning Urology Clinic, Mokpo); Seung Il Jung (Chonnam National University, Gwangju); Soo Dong Kim (Dong-A University, Busan); Kook Hyeong Hwang (HwangKookHyeong Urology Clinic, Busan); Chol Jong Back (Good Morning Urology Clinic, Daejeon); Sue Yong Sung (Su Hospital, Munmak); Woong Gyo Jung (JungWoongGyo Urology Clinic, Wonju); Seong Ho Lee (Hallym University Chuncheon Sacred Heart, Chuncheon); and Jung Sik Huh (Jeju National University, Jeju). This study was supported and funded by Korea Centers for Disease Control and Prevention, Seoul, Korea. This study was approved by a central ethical committee (Catholic Medical Centre, The Catholic University of Korea College of Medicine, Seoul, Korea, No. XCMC08OT015S) and then by the respective local ethical committees.

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N2 - The Korean Antimicrobial Resistance Monitoring System was established and the first nationwide surveillance of bacterial uropathogens was conducted during the period from January 2008 to June 2009. With the cooperation of 34 medical centers throughout South Korea, a total of 1994 strains belonging to clinically relevant bacterial uropathogens were collected from patients with community-acquired urinary tract infections (UTIs). To compare with past data, understand a trend of antimicrobial resistance, and ultimately determine new regimens for empirical treatment of uncomplicated cystitis, the antimicrobial susceptibilities against Escherichia coli in uncomplicated cystitis to commonly prescribed drugs were investigated. In uncomplicated cystitis, the most prevalent causative organism was E. coli (72.7%), followed by Enterococcus faecalis (10.7%) and Klebsiella pneumoniae (3.5%). Among E. coli isolates from acute uncomplicated cystitis, 38.5% were susceptible to ampicillin, 80.7% to amoxicillin/clavulanate, 67.3% to trimethoprim/sulfamethoxazole, 74.6% to ciprofloxacin, 77.5% to levofloxacin, 86.0% to cefazolin, 86.1% to cefuroxime, 93.6% to cefpodoxime, 94.7% to ceftriaxone, 99.5% to amikacin, 80.9% to tobramycin, and 76.6% to gentamicin. An increasing tendency of resistance to ciprofloxacin (24.8%) has been observed compared with the similar studies in 2006 (23.4%) and 2002 (15.2%) from patients with uncomplicated cystitis. These data provide much needed information on the prevalence of antimicrobial resistance in community-acquired UTIs in South Korea and will be a useful reference for future periodic surveillance studies.

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Antimicrobial resistance in community-acquired urinary tract infections: Results from the Korean Antimicrobial Resistance Monitoring System

Abstract

Bibliographical note

Keywords

UN SDGs

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