Antimicrobial activity of a conjugated polymer with cationic backbone

Qingling Xu, Ping He, Jianwu Wang, Hui Chen, Fengting Lv, Libing Liu, Shu Wang, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Owing to the misuse of antibiotics and slow development of new drugs, antibiotic-resistant pathogens have become a serious threat to human health. With the aim of developing new antimicrobial agents, we designed and synthesized a new conjugated polymer (PFPhim), which possesses an imidazolium containing backbone. The cationic backbone enables it to strongly interact with bacterial membrane leading to an antimicrobial ability that is more potent than that of a conjugated polymer containing a neutral backbone. PFPhim also displays strong photodynamic antimicrobial activity.

Original languageEnglish
Pages (from-to)519-523
Number of pages5
JournalDyes and Pigments
Volume160
DOIs
StatePublished - Jan 2019

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2012R1A3A2048814 for J. Yoon), the National Natural Science Foundation of China (No. 21533012 , No. 21708041 and No. 21473221 ) and Excellent Talents Project-Beijing Municipal Party Committee Organization Department ( 2017000097607G077 ). Mass spectral data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer.

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

  • Antimicrobial
  • Cationic backbone
  • Conjugated polymer
  • Imidazolium

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