Antimicrobial activity of a conjugated polymer with cationic backbone

Qingling Xu, Ping He, Jianwu Wang, Hui Chen, Fengting Lv, Libing Liu, Shu Wang, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Owing to the misuse of antibiotics and slow development of new drugs, antibiotic-resistant pathogens have become a serious threat to human health. With the aim of developing new antimicrobial agents, we designed and synthesized a new conjugated polymer (PFPhim), which possesses an imidazolium containing backbone. The cationic backbone enables it to strongly interact with bacterial membrane leading to an antimicrobial ability that is more potent than that of a conjugated polymer containing a neutral backbone. PFPhim also displays strong photodynamic antimicrobial activity.

Original languageEnglish
Pages (from-to)519-523
Number of pages5
JournalDyes and Pigments
Volume160
DOIs
StatePublished - Jan 2019

Keywords

  • Antimicrobial
  • Cationic backbone
  • Conjugated polymer
  • Imidazolium

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