Antimicrobial activity of a conjugated polymer with cationic backbone

Qingling Xu; Ping He; Jianwu Wang; Hui Chen; Fengting Lv; Libing Liu; Shu Wang; Juyoung Yoon

doi:10.1016/j.dyepig.2018.08.049

Antimicrobial activity of a conjugated polymer with cationic backbone

Qingling Xu, Ping He, Jianwu Wang, Hui Chen, Fengting Lv, Libing Liu, Shu Wang, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Owing to the misuse of antibiotics and slow development of new drugs, antibiotic-resistant pathogens have become a serious threat to human health. With the aim of developing new antimicrobial agents, we designed and synthesized a new conjugated polymer (PFPhim), which possesses an imidazolium containing backbone. The cationic backbone enables it to strongly interact with bacterial membrane leading to an antimicrobial ability that is more potent than that of a conjugated polymer containing a neutral backbone. PFPhim also displays strong photodynamic antimicrobial activity.

Original language	English
Pages (from-to)	519-523
Number of pages	5
Journal	Dyes and Pigments
Volume	160
DOIs	https://doi.org/10.1016/j.dyepig.2018.08.049
State	Published - Jan 2019

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2012R1A3A2048814 for J. Yoon), the National Natural Science Foundation of China (No. 21533012 , No. 21708041 and No. 21473221 ) and Excellent Talents Project-Beijing Municipal Party Committee Organization Department ( 2017000097607G077 ). Mass spectral data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer.

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

Antimicrobial
Cationic backbone
Conjugated polymer
Imidazolium

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dyepig.2018.08.049

Cite this

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title = "Antimicrobial activity of a conjugated polymer with cationic backbone",

abstract = "Owing to the misuse of antibiotics and slow development of new drugs, antibiotic-resistant pathogens have become a serious threat to human health. With the aim of developing new antimicrobial agents, we designed and synthesized a new conjugated polymer (PFPhim), which possesses an imidazolium containing backbone. The cationic backbone enables it to strongly interact with bacterial membrane leading to an antimicrobial ability that is more potent than that of a conjugated polymer containing a neutral backbone. PFPhim also displays strong photodynamic antimicrobial activity.",

keywords = "Antimicrobial, Cationic backbone, Conjugated polymer, Imidazolium",

author = "Qingling Xu and Ping He and Jianwu Wang and Hui Chen and Fengting Lv and Libing Liu and Shu Wang and Juyoung Yoon",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2012R1A3A2048814 for J. Yoon), the National Natural Science Foundation of China (No. 21533012 , No. 21708041 and No. 21473221 ) and Excellent Talents Project-Beijing Municipal Party Committee Organization Department ( 2017000097607G077 ). Mass spectral data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

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doi = "10.1016/j.dyepig.2018.08.049",

language = "English",

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T1 - Antimicrobial activity of a conjugated polymer with cationic backbone

AU - Xu, Qingling

AU - He, Ping

AU - Wang, Jianwu

AU - Chen, Hui

AU - Lv, Fengting

AU - Liu, Libing

AU - Wang, Shu

AU - Yoon, Juyoung

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2012R1A3A2048814 for J. Yoon), the National Natural Science Foundation of China (No. 21533012 , No. 21708041 and No. 21473221 ) and Excellent Talents Project-Beijing Municipal Party Committee Organization Department ( 2017000097607G077 ). Mass spectral data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer. Publisher Copyright: © 2018 Elsevier Ltd

PY - 2019/1

Y1 - 2019/1

N2 - Owing to the misuse of antibiotics and slow development of new drugs, antibiotic-resistant pathogens have become a serious threat to human health. With the aim of developing new antimicrobial agents, we designed and synthesized a new conjugated polymer (PFPhim), which possesses an imidazolium containing backbone. The cationic backbone enables it to strongly interact with bacterial membrane leading to an antimicrobial ability that is more potent than that of a conjugated polymer containing a neutral backbone. PFPhim also displays strong photodynamic antimicrobial activity.

AB - Owing to the misuse of antibiotics and slow development of new drugs, antibiotic-resistant pathogens have become a serious threat to human health. With the aim of developing new antimicrobial agents, we designed and synthesized a new conjugated polymer (PFPhim), which possesses an imidazolium containing backbone. The cationic backbone enables it to strongly interact with bacterial membrane leading to an antimicrobial ability that is more potent than that of a conjugated polymer containing a neutral backbone. PFPhim also displays strong photodynamic antimicrobial activity.

KW - Antimicrobial

KW - Cationic backbone

KW - Conjugated polymer

KW - Imidazolium

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M3 - Article

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VL - 160

SP - 519

EP - 523

JO - Dyes and Pigments

JF - Dyes and Pigments

ER -

Antimicrobial activity of a conjugated polymer with cationic backbone

Abstract

Bibliographical note

Keywords

UN SDGs

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