Antihypertensive treatment of acute intracerebral hemorrhage by intravenous nicardipine hydrochloride: Prospective multi-center study

Sung Kyun Hwang, Jong Soo Kim, Jung Hee Kim, Chang Ki Hong, Kook Hee Yang

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7 Scopus citations

Abstract

The authors performed a multicenter prospective study to evaluate the feasibility and safety of intravenous nicardipine hydrochloride for acute hypertension in patients with intracerebral hemorrhage (ICH). This study included 88 patients (mean age: 58.3 yr, range 26-87 yr) with ICH and acute hypertension in 5 medical centers between August 2008 and November 2010, who were treated using intravenous nicardipine. Administration of nicardipine resulted in a decrease from mean systolic blood pressure (BP) (175.4 ± 33.7 mmHg) and diastolic BP (100.8 ± 22 mmHg) at admission to mean systolic BP (127.4 ± 16.7 mmHg) and diastolic BP (67.2 ± 12.9 mmHg) in 6 hr after infusion (P < 0.001, mixed-effect linear models). Among patients who underwent follow-up by computed tomography, hematoma expansion at 24 hr (more than 33% increase in hematoma size at 24 hr) was observed in 3 (3.4%) of 88 patients. Neurological deterioration (defined as a decrease in initial Glasgow coma scale ≥ 2) was observed in 2 (2.2%) of 88 patients during the treatment. Aggressive nicardipine treatment of acute hypertension in patients with ICH can be safe and effective with a low rate of neurological deterioration and hematoma expansion.

Original languageEnglish
Pages (from-to)1085-1090
Number of pages6
JournalJournal of Korean Medical Science
Volume27
Issue number9
DOIs
StatePublished - Sep 2012

Keywords

  • Hypertension
  • Intracerebral hemorrhage
  • Nicardipine hydrochloride
  • Prospective studies

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