Antidepressant-like effect of chlorogenic acid isolated from Artemisia capillaris Thunb.

Soo Hyun Park, Yun Beom Sim, Pyung Lim Han, Jin Koo Lee, Hong Won Suh

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35 Scopus citations


Artemisia capillaris Thunb. is widely used in the herbal medicine field. This study describes the antidepressant effect of a flavonoid (chlorogenic acid) isolated from the Artemisia capillaris Thunb. The expression of the pituitary gland and hypothalamic POMC mRNA or plasma β-endorphin levels were increased by extract of Artemisia capillaries Thunb. or its flavoniod administered orally. In addition, antidepressant activity was studied using the tail suspension test (TST), the forced swimming test (FST) and the rotarod test in a chronically restrained immobilization stress group in mice. After restraint stress (2 h/day for 14 days), animals were kept in a cage for 14 days without any further stress, but with drugs. Mice were fed with a diet supplemented for 14 days and during the behavioral test period with chlorogenic acid (30 mg/kg/day). POMC mRNA or the plasma β-endorphin level was increased by the extract of Artemisia capillaris Thunb. and its flavoniod. In addition, the immobility time in TST and FST was significantly reduced by chlorogenic acid. In the rotarod test, the riding time remained similar to that of the control group at 15 rpm. Our results suggest that the flavonoid (chlorogenic acid) isolated from Artemisia capillaris Thunb. shows a potent antidepressant effect.

Original languageEnglish
Pages (from-to)253-259
Number of pages7
JournalAnimal Cells and Systems
Issue number4
StatePublished - 2010

Bibliographical note

Funding Information:
This research was supported by the Priority Research Centers Program through the National Research Foundation of Korea (NRF, 2009-0094072), the Medical Research Center program of MOST/KOSEF (2010-0009147), a Korea Research Foundation Grant funded by the Korean Government (MEST, The Regional Research Universities Program/Medical & Bio-Materials Research Center) and a grant (2010K000814) from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Education, Science and Technology, the Republic of Korea.


  • Antidepressant
  • Artemisia capillaris Thunb
  • Chlorogenic acid
  • β-endorphin


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