Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme

Nahoko Uchiyama; Zakayi Kabututu; Bruno K. Kubata; Fumiyuki Kiuchi; Michiho Ito; Junko Nakajima-Shimada; Takashi Aoki; Kei Ohkubo; Shunichi Fukuzumi; Samuel K. Martin; Gisho Honda; Yoshihiro Urade

doi:10.1128/AAC.49.12.5123-5126.2005

Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme

Nahoko Uchiyama
, Zakayi Kabututu
, Bruno K. Kubata
, Fumiyuki Kiuchi
, Michiho Ito
, Junko Nakajima-Shimada
, Takashi Aoki
, Kei Ohkubo
, Shunichi Fukuzumi
, Samuel K. Martin
, Gisho Honda
, Yoshihiro Urade

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs.

Original language	English
Pages (from-to)	5123-5126
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	49
Issue number	12
DOIs	https://doi.org/10.1128/AAC.49.12.5123-5126.2005
State	Published - Dec 2005

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10.1128/AAC.49.12.5123-5126.2005

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Uchiyama, N., Kabututu, Z., Kubata, B. K., Kiuchi, F., Ito, M., Nakajima-Shimada, J., Aoki, T., Ohkubo, K., Fukuzumi, S., Martin, S. K., Honda, G., & Urade, Y. (2005). Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme. Antimicrobial Agents and Chemotherapy, 49(12), 5123-5126. https://doi.org/10.1128/AAC.49.12.5123-5126.2005

@article{b201657d694344d2a42be078d1ba600b,

title = "Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme",

abstract = "A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs.",

author = "Nahoko Uchiyama and Zakayi Kabututu and Kubata, \{Bruno K.\} and Fumiyuki Kiuchi and Michiho Ito and Junko Nakajima-Shimada and Takashi Aoki and Kei Ohkubo and Shunichi Fukuzumi and Martin, \{Samuel K.\} and Gisho Honda and Yoshihiro Urade",

year = "2005",

month = dec,

doi = "10.1128/AAC.49.12.5123-5126.2005",

language = "English",

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pages = "5123--5126",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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}

Uchiyama, N, Kabututu, Z, Kubata, BK, Kiuchi, F, Ito, M, Nakajima-Shimada, J, Aoki, T, Ohkubo, K, Fukuzumi, S, Martin, SK, Honda, G & Urade, Y 2005, 'Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme', Antimicrobial Agents and Chemotherapy, vol. 49, no. 12, pp. 5123-5126. https://doi.org/10.1128/AAC.49.12.5123-5126.2005

TY - JOUR

T1 - Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme

AU - Uchiyama, Nahoko

AU - Kabututu, Zakayi

AU - Kubata, Bruno K.

AU - Kiuchi, Fumiyuki

AU - Ito, Michiho

AU - Nakajima-Shimada, Junko

AU - Aoki, Takashi

AU - Ohkubo, Kei

AU - Fukuzumi, Shunichi

AU - Martin, Samuel K.

AU - Honda, Gisho

AU - Urade, Yoshihiro

PY - 2005/12

Y1 - 2005/12

N2 - A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs.

AB - A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs.

UR - https://www.scopus.com/pages/publications/28844448181

U2 - 10.1128/AAC.49.12.5123-5126.2005

DO - 10.1128/AAC.49.12.5123-5126.2005

M3 - Article

C2 - 16304182

AN - SCOPUS:28844448181

SN - 0066-4804

VL - 49

SP - 5123

EP - 5126

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 12

ER -

Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme

Abstract

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