TY - JOUR
T1 - Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme
AU - Uchiyama, Nahoko
AU - Kabututu, Zakayi
AU - Kubata, Bruno K.
AU - Kiuchi, Fumiyuki
AU - Ito, Michiho
AU - Nakajima-Shimada, Junko
AU - Aoki, Takashi
AU - Ohkubo, Kei
AU - Fukuzumi, Shunichi
AU - Martin, Samuel K.
AU - Honda, Gisho
AU - Urade, Yoshihiro
PY - 2005/12
Y1 - 2005/12
N2 - A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs.
AB - A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs.
UR - http://www.scopus.com/inward/record.url?scp=28844448181&partnerID=8YFLogxK
U2 - 10.1128/AAC.49.12.5123-5126.2005
DO - 10.1128/AAC.49.12.5123-5126.2005
M3 - Article
C2 - 16304182
AN - SCOPUS:28844448181
SN - 0066-4804
VL - 49
SP - 5123
EP - 5126
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 12
ER -
