Antibacterial butenolides from the korean tunicate Pseudodistoma antinboja

Weihong Wang, Hiyoung Kim, Sang Jip Nam, Boon Jo Rho, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

Six new (1, 2, and 5-8) and three known (3, 4, and 9) butenolide metabolites were isolated from the tunicate Pseudodistoma antinboja by activity-guided fractionations. The structures were elucidated by combined NMR and MS spectroscopic methods. These compounds were evaluated for their antibacterial activity, and most of them exhibited moderate to significant activity that selectively targeted Gram-positive strains and did not exhibit cytotoxicity in the MTT assay at 100 μM. Cadiolides 5-9 in particular exhibited significant antibacterial activity that was comparable to or even better than those of marketed drugs such as vancomycin and linezolid against all of the drug-resistant strains tested.

Original languageEnglish
Pages (from-to)2049-2054
Number of pages6
JournalJournal of Natural Products
Volume75
Issue number12
DOIs
StatePublished - 28 Dec 2012

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