Antibacterial bicyclic fatty acids from a korean colonial tunicate didemnum sp.

Hiyoung Kim, Tae Gu Lee, Inho Yang, Weihong Wang, Jungwook Chin, Jusung Lee, Boon Jo Rho, Hyukjae Choi, Sang Jip Nam, Dongyup Hahn, Heonjoong Kang

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Five new bicyclic carboxylic acids were obtained by antibacterial activity-guided isolation from a Korean colonial tunicate Didemnum sp. Their structures were elucidated by the interpretation of NMR, MS and CD spectroscopic data. They all belong to the class of aplidic acids. Three of them were amide derivatives (1–3), and the other two were dicarboxylic derivatives (4 and 5). The absolute configurations were determined by a bisignate pattern of CD spectroscopy, which revealed that the absolute configurations of amides were opposite to those of dicarboxylates at every stereogenic centers. Compound 2 exhibited the most potent antibacterial activity (MIC, 2 µg/mL).

Original languageEnglish
Article number521
JournalMarine Drugs
Issue number9
StatePublished - Sep 2021

Bibliographical note

Funding Information:
Funding: This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Ministry of Science and ICT (NRF-2019R1A2C2005492) and the Ministry of Education (NRF-2019R1I1A1A01044151).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Antibacterial
  • Bicyclic fatty acids
  • Colonial tunicate
  • Didemnum


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