Antiadhesive effect of the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose after endoscopic sinus surgery

Jeong Hong Kim, Joo Hwan Lee, Joo Heon Yoon, Jung Hyun Chang, Jung Ho Bae, Kyung Su Kim

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Background: We evaluated the clinical efficacy and safety of the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose (HA-CMC) for prevention of adhesion after endoscopic sinus surgery. Methods: Preoperative computed tomography (CT) scans were graded. At the completion of surgery, HA-CMC was applied to Merocel and repeatedly applied after the removal of Merocel. As a control, normal saline was applied. Endoscopic examination was performed postoperatively and grading was done. Results: The rate of adhesion was the highest at 2 weeks postoperatively and was significantly lower in the HA-CMC-treated group than the control on all postoperative days. The grouping of cases by CT scores at 2 weeks postoperatively showed lower adhesion formation with the HA-CMC treatment than the control. The safety profile of the patients was normal at 4 weeks postoperatively. Conclusion: HA-CMC is an efficacious and safe material in decreasing the incidence of adhesion after endoscopic sinus surgery.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalAmerican Journal of Rhinology
Volume21
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Adhesion
  • Endoscopic sinus surgery
  • Postsurgical
  • Revision surgery
  • Sodium carboxymethylcellulose
  • Sodium hyaluronate
  • Surgical complication

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