Antiadhesive effect and safety of sodium hyaluronate-carboxymethyl cellulose membrane in thyroid surgery

Dong Sik Bae, Jung Woo Woo, Se Hyun Paek, Hyungju Kwon, Young Jun Chai, Su Jin Kim, June Young Choi, Kyu Eun Lee, Yeo Kyu Youn

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Purpose: a number of researchers have suggested the use of sodium hyalu ronate ca rboxy methyl cellu lose (HA-CMC) membra ne for preventin g postop erative adhesion. This study evaluated the antiadhesive effect and safety of HA-CMC membrane in thyroidectomy for papillary thyroid cancer. Methods: One hundred sixty-two patients who underwent thyroidectomy were prospectively randomized. In the study group of 80 patients, the 7.5 cm × 13 cm HA-CMC membrane was applied to the operative field after thyroidectomy. The subjects were asked about complications including adhesive symptoms using an 8-item questionnaire at 2 weeks, 3 months, and 6 months after surgery. In addition, items on the appearance of neck wrinkles and scars were evaluated by a physician who had no information about the patient's allocation. Results: There were no significant differences in complications such as swallowing difficulty, and wrinkles between study and control groups. Both groups presented significantly decreased scores over time in swallowing difficulty, and wrinkles. There were no complications regarding the HA-CMC membrane. Conclusion: The antiadhesive effect of HA-CMC membrane in thyroid surgery is still uncertain, although it is biologically safe. Further investigation is needed to confirm the antiadhesive effect of HA-CMC membrane in thyroid surgery.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalJournal of the Korean Surgical Society
Volume85
Issue number5
DOIs
StatePublished - Nov 2013

Keywords

  • Adhesion
  • HA-CMC
  • Seprafilm
  • Sodium hyaluronate carboxymethyl cellulose
  • Thyroid

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