Anti-respiratory syncytial virus (RSV) activity of timosaponin A-III from the rhizomes of Anemarrhena asphodeloides

Ui Joung Youn; Ji Eun Jang; Joo Won Nam; Yoo Jin Lee; Young Min Son; Hyun Ji Shin; Ah Reum Han; Jun Chang; Eun Kyoung Seo

Anti-respiratory syncytial virus (RSV) activity of timosaponin A-III from the rhizomes of Anemarrhena asphodeloides

Ui Joung Youn
, Ji Eun Jang
, Joo Won Nam
, Yoo Jin Lee
, Young Min Son
, Hyun Ji Shin
, Ah Reum Han
, Jun Chang
, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Two known steroidal saponins, timosaponin A-III (1) and anemarsaponin B (2) were isolated from the BuOH fraction of the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae) together with the xanthone derivatives, mangiferin (3) and neomangiferin (4). Structures of the isolates were identified using 1D and 2D NMR techniques and by comparison with the published values. Timosaponin A-III (1) exhibited potent inhibitory effects on the respiratory syncytial virus (RSV), with an IC ₅₀ value of 1.00 μM.

Original language	English
Pages (from-to)	1062-1065
Number of pages	4
Journal	Journal of Medicinal Plants Research
Volume	5
Issue number	7
State	Published - 4 Apr 2011

Keywords

Anemarrhena asphodeloides
Liliaceae
Respiratory syncytial virus (RSV)
Timosaponin A-III

Cite this

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title = "Anti-respiratory syncytial virus (RSV) activity of timosaponin A-III from the rhizomes of Anemarrhena asphodeloides",

abstract = "Two known steroidal saponins, timosaponin A-III (1) and anemarsaponin B (2) were isolated from the BuOH fraction of the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae) together with the xanthone derivatives, mangiferin (3) and neomangiferin (4). Structures of the isolates were identified using 1D and 2D NMR techniques and by comparison with the published values. Timosaponin A-III (1) exhibited potent inhibitory effects on the respiratory syncytial virus (RSV), with an IC 50 value of 1.00 μM.",

keywords = "Anemarrhena asphodeloides, Liliaceae, Respiratory syncytial virus (RSV), Timosaponin A-III",

author = "Youn, \{Ui Joung\} and Jang, \{Ji Eun\} and Nam, \{Joo Won\} and Lee, \{Yoo Jin\} and Son, \{Young Min\} and Shin, \{Hyun Ji\} and Han, \{Ah Reum\} and Jun Chang and Seo, \{Eun Kyoung\}",

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language = "English",

volume = "5",

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journal = "Journal of Medicinal Plants Research",

issn = "1996-0875",

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T1 - Anti-respiratory syncytial virus (RSV) activity of timosaponin A-III from the rhizomes of Anemarrhena asphodeloides

AU - Youn, Ui Joung

AU - Jang, Ji Eun

AU - Nam, Joo Won

AU - Lee, Yoo Jin

AU - Son, Young Min

AU - Shin, Hyun Ji

AU - Han, Ah Reum

AU - Chang, Jun

AU - Seo, Eun Kyoung

PY - 2011/4/4

Y1 - 2011/4/4

N2 - Two known steroidal saponins, timosaponin A-III (1) and anemarsaponin B (2) were isolated from the BuOH fraction of the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae) together with the xanthone derivatives, mangiferin (3) and neomangiferin (4). Structures of the isolates were identified using 1D and 2D NMR techniques and by comparison with the published values. Timosaponin A-III (1) exhibited potent inhibitory effects on the respiratory syncytial virus (RSV), with an IC 50 value of 1.00 μM.

AB - Two known steroidal saponins, timosaponin A-III (1) and anemarsaponin B (2) were isolated from the BuOH fraction of the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae) together with the xanthone derivatives, mangiferin (3) and neomangiferin (4). Structures of the isolates were identified using 1D and 2D NMR techniques and by comparison with the published values. Timosaponin A-III (1) exhibited potent inhibitory effects on the respiratory syncytial virus (RSV), with an IC 50 value of 1.00 μM.

KW - Anemarrhena asphodeloides

KW - Liliaceae

KW - Respiratory syncytial virus (RSV)

KW - Timosaponin A-III

UR - https://www.scopus.com/pages/publications/79955565343

M3 - Article

AN - SCOPUS:79955565343

SN - 1996-0875

VL - 5

SP - 1062

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JO - Journal of Medicinal Plants Research

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IS - 7

ER -

Anti-respiratory syncytial virus (RSV) activity of timosaponin A-III from the rhizomes of Anemarrhena asphodeloides

Abstract

Keywords

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