Anti-pigmentary natural compounds and their mode of action

Kyuri Kim, Yoonjung Huh, Kyung Min Lim

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Hyper-activated melanocytes are the major cause of skin hyper-pigmentary disorders, such as freckles and melasma. Increasing efforts have been made to search for materials with depigmenting activity to develop functional cosmetics. As a result, numerous materials have been reported to have depigmenting activity but some of them are known to cause unwanted side effects. Consequently, anti-pigmentary natural compounds without concern of toxicity are in great demand. Virtually all sorts of natural sources have been investigated to find anti-pigmentary natural compounds. This review summarizes recently reported anti-pigmentary natural compounds and their mode of action from the ocean, plants, and bacteria.

Original languageEnglish
Article number6206
JournalInternational Journal of Molecular Sciences
Issue number12
StatePublished - 2 Jun 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Melanogenesis
  • Natural compound
  • Skin pigmentation
  • Tyrosinase


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