Anti-pigmentary effect of (-)-4-hydroxysattabacin from the marine-derived bacterium Bacillus sp.

Kyuri Kim, Alain S. Leutou, Haein Jeong, Dayoung Kim, Chi Nam Seong, Sang Jip Nam, Kyung Min Lim

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14 Scopus citations


Bioactivity-guided isolation of a crude extract from a culture broth of Bacillus sp. has led to the isolation of (-)-4-hydroxysattabacin (1). The inhibitory effect of (-)-4-hydroxysattabacin (1) was investigated on melanogenesis in the murine melanoma cell line, B16F10, and human melanoma cell line, MNT-1, as well as a pigmented 3D-human skin model. (-)-4-Hydroxysattabacin treatment decreased melanin contents in a dose-dependent manner in α-melanocyte stimulating hormone (α-MSH)-stimulated B16F10 cells. Quantitative real time PCR (qRT-PCR) demonstrated that treatment with (-)-4-hydroxysattabacin down-regulated several melanogenic genes, including tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) while their enzymatic activities were unaffected. The anti-melanogenic effects of (-)-4-hydroxysattabacin were further demonstrated in a pigmented 3D human epidermal skin model, Melanoderm™, and manifested as whitening and regression of melanocyte activation in the tissue.

Original languageEnglish
Article number138
JournalMarine Drugs
Issue number5
StatePublished - May 2017


  • (-)-4-Hydroxysattabacin
  • Anti-pigmentary effect
  • Bacillus sp.
  • Marine-derived
  • Melanogenesis


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