Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet

Joo Yeon Kim, Mak Soon Lee, Sunyoon Jung, Hyunjin Joo, Chong Tai Kim, In Hwan Kim, Sangjin Seo, Soojung Oh, Yangha Kim

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Purpose: This study determined the effects of oleoresin capsicum (OC) and nanoemulsion OC (NOC) on obesity in obese rats fed a high-fat diet. Methods: The rats were randomly separated into three groups: a high-fat (HF) diet group, HF + OC diet group, and HF + NOC diet group. All groups were fed the diet and water ad libitum for 14 weeks. Results: NOC reduced the body weight and adipose tissue mass, whereas OC did not. OC and NOC reduced mRNA levels of adipogenic genes, including peroxisome proliferator-activated receptor (PPAR)-γ, sterol regulatory element-binding protein-1c, and fatty acid-binding protein in white adipose tissue. The mRNA levels of genes related to β-oxidation or thermogenesis including PPAR-α, palmitoyltransferase-1α, and uncoupling protein-2 were increased by the OC and NOC relative to the HF group. Both OC and NOC clearly stimulated AMP-activated protein kinase (AMPK) activity. In particular, PPAR-α, palmitoyltransferase-1α, uncoupling protein-2 expression, and AMPK activity were significantly increased in the NOC group compared to in the OC group. NOC decreased glycerol-3-phosphate dehydrogenase activity whereas OC did not. Conclusion: From these results, NOC could be suggested as a potential anti-obesity agent in obese rats fed a HF diet. The effects of the NOC on obesity were associated with changes of multiple gene expression, activation of AMPK, and inhibition of glycerol-3-phosphate dehy-drogenase in white adipose tissue.

Original languageEnglish
Pages (from-to)301-310
Number of pages10
JournalInternational Journal of Nanomedicine
Issue number1
StatePublished - 3 Jan 2014


  • Amp-activated protein kinase
  • Anti-obesity
  • Gene expression
  • Nanoemulsion
  • Oleoresin capsicum
  • Rats


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