Rhodosporidium toruloides, an oleaginous yeast, can be used as a fast and reliable evaluation tool to screen new natural lipid-lowering agents. Herein, we showed that triglyceride (TG) accumulation was inhibited by 42.6% in 0.1% red radish coral sprout extract (RRSE)-treated R. toruloides. We also evaluated the anti-obesity effect of the RRSE in a mouse model. The body weight gain of mice fed a high-fat diet (HFD) with 0.1% RRSE (HFD-RRSE) was significantly decreased by 60% compared with that mice fed the HFD alone after the 8-week experimental period. Body fat of the HFD-RRSE-fed group was dramatically reduced by 38.3% compared with that of the HFD-fed group.
Bibliographical noteFunding Information:
This research was supported by Establishment of Infrastructure for Industrialization of Korean Useful Microbes, MOTIE, Korea Institute for the Advancement of Technology (KIAT, R0004073), by the Jeonbuk Research & Development Program funded by Jeonbuk Province (Grant No. 201 40929-A-001 ), by the High Value-added Food Technology Development Program, Ministry of Agriculture, Food and Rural Affairs (MAFRA), Republic of Korea (31 6058-3, 31 5063-3), and by the Functional Districts of the Science Belt Support Program, Ministry of Science, ICT and Future Planning, Republic of Korea (2017K000017).
© 2018 by The Korean Society for Microbiology and Biotechnology.
- Red radish coral sprout
- Rhodosporidium toruloides