TY - JOUR
T1 - Anti-Mullerian hormone and endometrial cancer
T2 - A multi-cohort study
AU - Fortner, Renée T.
AU - Schock, Helena
AU - Jung, Seungyoun
AU - Allen, Naomi E.
AU - Arslan, Alan A.
AU - Brinton, Louise A.
AU - Egleston, Brian L.
AU - Falk, Roni T.
AU - Gunter, Marc J.
AU - Helzlsouer, Kathy J.
AU - Idahl, Annika
AU - Johnson, Theron S.
AU - Kaaks, Rudolf
AU - Krogh, Vittorio
AU - Lundin, Eva
AU - Merritt, Melissa A.
AU - Navarro, Carmen
AU - Onland-Moret, N. Charlotte
AU - Palli, Domenico
AU - Shu, Xiao Ou
AU - Sluss, Patrick M.
AU - Staats, Paul N.
AU - Trichopoulou, Antonia
AU - Weiderpass, Elisabete
AU - Zeleniuch-Jacquotte, Anne
AU - Zheng, Wei
AU - Dorgan, Joanne F.
N1 - Publisher Copyright:
© 2017 Cancer Research UK. All Rights Reserved.
PY - 2017
Y1 - 2017
N2 - Background: TheMullerian ducts are the embryological precursors of the female reproductive tract, including the uterus; anti-Mullerian hormone (AMH) has a key role in the regulation of foetal sexual differentiation. Anti-Mullerian hormone inhibits endometrial tumour growth in experimental models by stimulating apoptosis and cell cycle arrest. To date, there are no prospective epidemiologic data on circulating AMH and endometrial cancer risk. Methods: We investigated this association among women premenopausal at blood collection in a multicohort study including participants from eight studies located in the United States, Europe, and China. We identified 329 endometrial cancer cases and 339 matched controls. Anti- Mullerian hormone concentrations in blood were quantified using an enzyme-linked immunosorbent assay. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) across tertiles and for a doubling of AMH concentrations (ORlog2). Subgroup analyses were performed by ages at blood donation and diagnosis, oral contraceptive use, and tumour characteristics. Results: Anti-Mullerian hormone was not associated with the risk of endometrial cancer overall (ORlog2: 1.07 (0.99-1.17)), or with any of the examined subgroups. Conclusions: Although experimental models implicate AMH in endometrial cancer growth inhibition, our findings do not support a role for circulating AMH in the aetiology of endometrial cancer.
AB - Background: TheMullerian ducts are the embryological precursors of the female reproductive tract, including the uterus; anti-Mullerian hormone (AMH) has a key role in the regulation of foetal sexual differentiation. Anti-Mullerian hormone inhibits endometrial tumour growth in experimental models by stimulating apoptosis and cell cycle arrest. To date, there are no prospective epidemiologic data on circulating AMH and endometrial cancer risk. Methods: We investigated this association among women premenopausal at blood collection in a multicohort study including participants from eight studies located in the United States, Europe, and China. We identified 329 endometrial cancer cases and 339 matched controls. Anti- Mullerian hormone concentrations in blood were quantified using an enzyme-linked immunosorbent assay. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) across tertiles and for a doubling of AMH concentrations (ORlog2). Subgroup analyses were performed by ages at blood donation and diagnosis, oral contraceptive use, and tumour characteristics. Results: Anti-Mullerian hormone was not associated with the risk of endometrial cancer overall (ORlog2: 1.07 (0.99-1.17)), or with any of the examined subgroups. Conclusions: Although experimental models implicate AMH in endometrial cancer growth inhibition, our findings do not support a role for circulating AMH in the aetiology of endometrial cancer.
UR - http://www.scopus.com/inward/record.url?scp=85033397473&partnerID=8YFLogxK
U2 - 10.1038/bjc.2017.299
DO - 10.1038/bjc.2017.299
M3 - Article
C2 - 28873086
AN - SCOPUS:85033397473
SN - 0007-0920
VL - 117
SP - 1412
EP - 1418
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 9
ER -