Anti-inflammatory mechanism of ginseng saponins in activated microglia

Jin Sun Park; Eun Mi Park; Dong Hyun Kim; Kangsik Jung; Ji Sun Jung; Eun Jung Lee; Jin Won Hyun; Jihee Lee Kang; Hee Sun Kim

doi:10.1016/j.jneuroim.2009.01.020

Anti-inflammatory mechanism of ginseng saponins in activated microglia

Jin Sun Park, Eun Mi Park, Dong Hyun Kim, Kangsik Jung, Ji Sun Jung, Eun Jung Lee, Jin Won Hyun, Jihee Lee Kang, Hee Sun Kim

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

In the present study, we investigated the effect of ginseng extract (KRG) and total saponins (GTS) on microglial activation. KRG and GTS inhibited LPS-induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells. Suppression of microglial activation by ginseng was also observed in the mouse brain inflamed by LPS. Furthermore, KRG and GTS significantly suppressed NF-κB and MAP kinase activities, which are upstream signaling molecules in inflammation. Among the individual ginsenosides tested, Rh2, Rh3 and compound K significantly inhibited LPS-induced iNOS and cytokine expressions. Therefore, the inhibition of microglial activation by ginseng saponins may a good potential therapeutic modality for neurodegenerative diseases.

Original language	English
Pages (from-to)	40-49
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	209
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2009.01.020
State	Published - 30 Apr 2009

Bibliographical note

Funding Information:
This work was supported by a grant (2007) from the Korean Society of Ginseng funded by the Korea Ginseng Cooperation.

Keywords

Cytokine
Ginseng saponin
Microglia
Signaling pathway
iNOS

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10.1016/j.jneuroim.2009.01.020

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title = "Anti-inflammatory mechanism of ginseng saponins in activated microglia",

abstract = "In the present study, we investigated the effect of ginseng extract (KRG) and total saponins (GTS) on microglial activation. KRG and GTS inhibited LPS-induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells. Suppression of microglial activation by ginseng was also observed in the mouse brain inflamed by LPS. Furthermore, KRG and GTS significantly suppressed NF-κB and MAP kinase activities, which are upstream signaling molecules in inflammation. Among the individual ginsenosides tested, Rh2, Rh3 and compound K significantly inhibited LPS-induced iNOS and cytokine expressions. Therefore, the inhibition of microglial activation by ginseng saponins may a good potential therapeutic modality for neurodegenerative diseases.",

keywords = "Cytokine, Ginseng saponin, Microglia, Signaling pathway, iNOS",

author = "Park, {Jin Sun} and Park, {Eun Mi} and Kim, {Dong Hyun} and Kangsik Jung and Jung, {Ji Sun} and Lee, {Eun Jung} and Hyun, {Jin Won} and Kang, {Jihee Lee} and Kim, {Hee Sun}",

note = "Funding Information: This work was supported by a grant (2007) from the Korean Society of Ginseng funded by the Korea Ginseng Cooperation.",

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doi = "10.1016/j.jneuroim.2009.01.020",

language = "English",

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T1 - Anti-inflammatory mechanism of ginseng saponins in activated microglia

AU - Park, Jin Sun

AU - Park, Eun Mi

AU - Kim, Dong Hyun

AU - Jung, Kangsik

AU - Jung, Ji Sun

AU - Lee, Eun Jung

AU - Hyun, Jin Won

AU - Kang, Jihee Lee

AU - Kim, Hee Sun

N1 - Funding Information: This work was supported by a grant (2007) from the Korean Society of Ginseng funded by the Korea Ginseng Cooperation.

PY - 2009/4/30

Y1 - 2009/4/30

N2 - In the present study, we investigated the effect of ginseng extract (KRG) and total saponins (GTS) on microglial activation. KRG and GTS inhibited LPS-induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells. Suppression of microglial activation by ginseng was also observed in the mouse brain inflamed by LPS. Furthermore, KRG and GTS significantly suppressed NF-κB and MAP kinase activities, which are upstream signaling molecules in inflammation. Among the individual ginsenosides tested, Rh2, Rh3 and compound K significantly inhibited LPS-induced iNOS and cytokine expressions. Therefore, the inhibition of microglial activation by ginseng saponins may a good potential therapeutic modality for neurodegenerative diseases.

AB - In the present study, we investigated the effect of ginseng extract (KRG) and total saponins (GTS) on microglial activation. KRG and GTS inhibited LPS-induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells. Suppression of microglial activation by ginseng was also observed in the mouse brain inflamed by LPS. Furthermore, KRG and GTS significantly suppressed NF-κB and MAP kinase activities, which are upstream signaling molecules in inflammation. Among the individual ginsenosides tested, Rh2, Rh3 and compound K significantly inhibited LPS-induced iNOS and cytokine expressions. Therefore, the inhibition of microglial activation by ginseng saponins may a good potential therapeutic modality for neurodegenerative diseases.

KW - Cytokine

KW - Ginseng saponin

KW - Microglia

KW - Signaling pathway

KW - iNOS

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M3 - Article

C2 - 19232442

AN - SCOPUS:64549126462

SN - 0165-5728

VL - 209

SP - 40

EP - 49

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Anti-inflammatory mechanism of ginseng saponins in activated microglia

Abstract

Bibliographical note

Keywords

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