Anti-inflammatory effects of Rubus coreanus Miquel through inhibition of NF-κB and MAP kinase

Jung Eun Lee, Soo Muk Cho, Eunkyo Park, Seung Min Lee, Yuri Kim, Joong Hyuck Auh, Hyung Kyoon Choi, Sohee Lim, Sung Chul Lee, Jung Hyun Kim

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


MATERIALS/METHODS: Unripe RCM ethanol extract (UE), unripe RCM water extract (UH), ripe RCM ethanol extract (RE), and ripe RCM water extract (RH) were prepared. Inflammatory response was induced with LPS treatment, and expression of pro-inflammatory mediators (iNOS, COX-2, TNF-α, IL-1β, and IL-6) and NO and PGE2 productions were assessed. To determine the anti-inflammatory mechanism of RCM, we measured NF-κB and MAPK activities.

RESULTS: UE and UH treatment significantly reduced NF-κB activation and JNK and p38 phosphorylation and reduced transcriptional activities decreased iNOS, COX-2, and pro-inflammatory cytokines expressions, and NO and PGE2 productions. RE and RH treatments reduced IL-1β and IL-6 expressions through suppressions of JNK and p38 phosphorylation.

CONCLUSIONS: In this study, we showed that RCM had anti-inflammatory effects by suppression of pro-inflammatory mediator expressions. Especially, unripe RCM showed strong anti-inflammatory effects through suppression of NF-κB and MAPK activation. These findings suggest that unripe RCM might be used as a potential functional material to reduce chronic inflammatory responses.

BACKGROUND/OBJECTIVES: Rubus Coreanus Miquel (RCM), used as a traditional Korean medicine, reduces chronic inflammatory diseases such as cancer and rheumatoid arthritis. However, its mechanism has not been elucidated. In this study, we examine the anti-inflammatory effects of RCM and their possible mechanisms using RAW 264.7 cells.

Original languageEnglish
Pages (from-to)501-508
Number of pages8
JournalNutrition Research and Practice
Issue number5
StatePublished - 1 Oct 2014

Bibliographical note

Publisher Copyright:
© 2014 The Korean Nutrition Society and the Korean Society of Community Nutrition.


  • Cytokines
  • Inflammation
  • MAPK
  • NF-κB
  • Rubus coreanus Miquel


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