Anti-inflammatory effects of catalpalactone isolated from catalpa ovata in LPS-induced RAW264.7 cells

Hyo Young Kim, Ah Reum Han, Yun Seo Kil, Eun Kyoung Seo, Chang Hyun Jin

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Catalpa ovata (Bignoniaceae) is widely distributed throughout Korea, China, and Japan. This study investigated the anti-inflammatory effects of catalpalactone isolated from C. ovata in lipopolysaccharide (LPS)-induced RAW264.7 cells. Catalpalactone significantly inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) expression in LPS-induced RAW264.7 cells. The levels of cytokines such as interleukin-6 and tumor necrosis factor-α were reduced under catalpalactone exposure in LPS-induced RAW264.7 cells. Additionally, catalpalactone suppressed signal transducer and activator of transcription 1 (STAT-1) protein expression and interferon-β (IFN-β) production. Treatment with catalpalactone prevented interferon regulatory factor 3 (IRF3) and nuclear factor-κB (NF-κB) activation. Taken together, these results suggest that the anti-inflammatory effects of catalpalactone are associated with the suppression of NO production and iNOS expression through the inhibition of IRF3, NF-κB, and IFN-β/STAT-1 activation.

Original languageEnglish
Article number1236
JournalMolecules
Volume24
Issue number7
DOIs
StatePublished - 29 Mar 2019

Bibliographical note

Publisher Copyright:
© 2019 by the authors.

Keywords

  • Catalpa ovata
  • Catalpalactone
  • IRF3
  • Lipopolysaccharide
  • NF-κB

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