Anti-inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver

Ji Yeon Yu, Jae Yeo Ha, Kyung Mi Kim, Young Suk Jung, Jae Chul Jung, Seikwan Oh

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

This study provides the scientific basis for the anti-inflammatory effects of licorice extract in a t-BHP (tert-butyl hydrogen peroxide)-induced liver damage model and the effects of its ingredients, glycyrrhizic acid (GA), liquiritin (LQ) and liquiritigenin (LG), in a lipopolysaccharide (LPS)-stimulated microglial cell model. The GA, LQ and LG inhibited the LPS-stimulated elevation of pro-inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and interleukin (IL)-6 in BV2 (mouse brain microglia) cells. Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in the livers of t-BHP-treated mice models. This result suggested that mechanistic-based evidence substantiating the traditional claims of licorice extract and its three bioactive components can be applied for the treatment of inflammation-related disorders, such as oxidative liver damage and inflammation diseases.

Original languageEnglish
Pages (from-to)13041-13054
Number of pages14
JournalMolecules
Volume20
Issue number7
DOIs
StatePublished - 1 Jul 2015

Keywords

  • Anti-inflammation
  • Glycyrrhizic acid
  • Hepatoprotective effect
  • Licorice extract
  • Liquiritin
  • Oxidative liver damage

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