Anti-apoptosis engineering

Eun Jeong Kim, Tai Hyun Park

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


An increased understanding of apoptosis makes anti-apoptosis engineering possible, which is an approach used to inhibit apoptosis for the purpose of therapeutic, or industrial applications in the treatment of the diseases associated with increased apoptosis, or to improve the productivity of animal cell cultures, respectively. Some known anti-apoptotic proteins are the Bcl-2 family, IAP (inhibitor of apoptosis) and Hsps (heat shock proteins), with which anti-apoptosis engineering has progressed. This article reviews anti-apoptosis engineering using known anti-apoptotic compounds, and introduces a 30 K protein, isolated from silkworm hemolymph, as a novel anti-apoptotic protein, that shows no homology with other known anti-apoptotic proteins. The regulation of apoptosis, using anti-apoptotic proteins and genes originating from the silkworm, Bombyx mori, may provide a new strategy in this field.

Original languageEnglish
Pages (from-to)76-82
Number of pages7
JournalBiotechnology and Bioprocess Engineering
Issue number2
StatePublished - 2003


  • 30K protein
  • Anti-apoptosis engineering
  • Apoptosis
  • Bcl-2 family
  • Hsps
  • IAP


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