Anti-adipogenic and anti-diabetic effects of cis-3′,4′-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro

Ra Yeong Choi, Sang Jip Nam, Ju Ri Ham, Hae In Lee, Sung Tae Yee, Kyung Yun Kang, Kwon Il Seo, Ju Hye Lee, Myung Joo Kim, Mi Kyung Lee

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Peucedanum japonicum Thunb is a medicinal plant belonging to the family Umbelliferae. This study evaluated the anti-diabetic and anti-obesity effects of cis-3′,4′-diisovalerylkhellactone (cDIVK) isolated from Peucedanum japonicum Thunb leaves. cDIVK (30 and 50 μM) effectively inhibited adipocyte differentiation and fat accumulation, whereas it stimulated glucose uptake compared with the control in 3T3-L1 cells. cDIVK significantly increased AMPK activation and suppressed protein and mRNA expression of major adipogenic transcriptional factors such as C/EBPα, PPARγ and SREBP-1c in 3T3-L1 cells. In addition, cDIVK had potential α-glucosidase inhibitory activity. These results indicated that cDIVK may act as a natural dual therapeutic agent for diabetes and obesity.

Original languageEnglish
Pages (from-to)4655-4660
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number19
DOIs
StatePublished - 2016

Keywords

  • Adipocytes
  • Adipogenesis
  • Anti-diabetes
  • Anti-obesity
  • Peucedanum japonicum Thunb leaves

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