Anti-adipogenic and anti-diabetic effects of cis-3′,4′-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro

Ra Yeong Choi; Sang Jip Nam; Ju Ri Ham; Hae In Lee; Sung Tae Yee; Kyung Yun Kang; Kwon Il Seo; Ju Hye Lee; Myung Joo Kim; Mi Kyung Lee

doi:10.1016/j.bmcl.2016.08.056

Anti-adipogenic and anti-diabetic effects of cis-3′,4′-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro

Ra Yeong Choi, Sang Jip Nam, Ju Ri Ham, Hae In Lee, Sung Tae Yee, Kyung Yun Kang, Kwon Il Seo, Ju Hye Lee, Myung Joo Kim, Mi Kyung Lee

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Peucedanum japonicum Thunb is a medicinal plant belonging to the family Umbelliferae. This study evaluated the anti-diabetic and anti-obesity effects of cis-3′,4′-diisovalerylkhellactone (cDIVK) isolated from Peucedanum japonicum Thunb leaves. cDIVK (30 and 50 μM) effectively inhibited adipocyte differentiation and fat accumulation, whereas it stimulated glucose uptake compared with the control in 3T3-L1 cells. cDIVK significantly increased AMPK activation and suppressed protein and mRNA expression of major adipogenic transcriptional factors such as C/EBPα, PPARγ and SREBP-1c in 3T3-L1 cells. In addition, cDIVK had potential α-glucosidase inhibitory activity. These results indicated that cDIVK may act as a natural dual therapeutic agent for diabetes and obesity.

Original language	English
Pages (from-to)	4655-4660
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	19
DOIs	https://doi.org/10.1016/j.bmcl.2016.08.056
State	Published - 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

Adipocytes
Adipogenesis
Anti-diabetes
Anti-obesity
Peucedanum japonicum Thunb leaves

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2016.08.056

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Choi, R. Y., Nam, S. J., Ham, J. R., Lee, H. I., Yee, S. T., Kang, K. Y., Seo, K. I., Lee, J. H., Kim, M. J., & Lee, M. K. (2016). Anti-adipogenic and anti-diabetic effects of cis-3′,4′-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro. Bioorganic and Medicinal Chemistry Letters, 26(19), 4655-4660. https://doi.org/10.1016/j.bmcl.2016.08.056

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abstract = "Peucedanum japonicum Thunb is a medicinal plant belonging to the family Umbelliferae. This study evaluated the anti-diabetic and anti-obesity effects of cis-3′,4′-diisovalerylkhellactone (cDIVK) isolated from Peucedanum japonicum Thunb leaves. cDIVK (30 and 50 μM) effectively inhibited adipocyte differentiation and fat accumulation, whereas it stimulated glucose uptake compared with the control in 3T3-L1 cells. cDIVK significantly increased AMPK activation and suppressed protein and mRNA expression of major adipogenic transcriptional factors such as C/EBPα, PPARγ and SREBP-1c in 3T3-L1 cells. In addition, cDIVK had potential α-glucosidase inhibitory activity. These results indicated that cDIVK may act as a natural dual therapeutic agent for diabetes and obesity.",

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author = "Choi, {Ra Yeong} and Nam, {Sang Jip} and Ham, {Ju Ri} and Lee, {Hae In} and Yee, {Sung Tae} and Kang, {Kyung Yun} and Seo, {Kwon Il} and Lee, {Ju Hye} and Kim, {Myung Joo} and Lee, {Mi Kyung}",

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doi = "10.1016/j.bmcl.2016.08.056",

language = "English",

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AU - Nam, Sang Jip

AU - Ham, Ju Ri

AU - Lee, Hae In

AU - Yee, Sung Tae

AU - Kang, Kyung Yun

AU - Seo, Kwon Il

AU - Lee, Ju Hye

AU - Kim, Myung Joo

AU - Lee, Mi Kyung

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AB - Peucedanum japonicum Thunb is a medicinal plant belonging to the family Umbelliferae. This study evaluated the anti-diabetic and anti-obesity effects of cis-3′,4′-diisovalerylkhellactone (cDIVK) isolated from Peucedanum japonicum Thunb leaves. cDIVK (30 and 50 μM) effectively inhibited adipocyte differentiation and fat accumulation, whereas it stimulated glucose uptake compared with the control in 3T3-L1 cells. cDIVK significantly increased AMPK activation and suppressed protein and mRNA expression of major adipogenic transcriptional factors such as C/EBPα, PPARγ and SREBP-1c in 3T3-L1 cells. In addition, cDIVK had potential α-glucosidase inhibitory activity. These results indicated that cDIVK may act as a natural dual therapeutic agent for diabetes and obesity.

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KW - Adipogenesis

KW - Anti-diabetes

KW - Anti-obesity

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Anti-adipogenic and anti-diabetic effects of cis-3′,4′-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro

Abstract

Bibliographical note

Keywords

UN SDGs

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