Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete

Kyoung Hwa Jang; Sang Jip Nam; Jeffrey B. Locke; Christopher A. Kauffman; Deanna S. Beatty; Lauren A. Paul; William Fenical

doi:10.1002/anie.201302749

Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete

Kyoung Hwa Jang, Sang Jip Nam, Jeffrey B. Locke, Christopher A. Kauffman, Deanna S. Beatty, Lauren A. Paul, William Fenical

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria.

Original language	English
Pages (from-to)	7822-7824
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	30
DOIs	https://doi.org/10.1002/anie.201302749
State	Published - 22 Jul 2013

Keywords

anthrax
antibiotics
bacillus anthracis
natural products
polyketides

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title = "Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete",

abstract = "Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria.",

keywords = "anthrax, antibiotics, bacillus anthracis, natural products, polyketides",

author = "Jang, \{Kyoung Hwa\} and Nam, \{Sang Jip\} and Locke, \{Jeffrey B.\} and Kauffman, \{Christopher A.\} and Beatty, \{Deanna S.\} and Paul, \{Lauren A.\} and William Fenical",

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AU - Jang, Kyoung Hwa

AU - Nam, Sang Jip

AU - Locke, Jeffrey B.

AU - Kauffman, Christopher A.

AU - Beatty, Deanna S.

AU - Paul, Lauren A.

AU - Fenical, William

PY - 2013/7/22

Y1 - 2013/7/22

N2 - Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria.

AB - Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria.

KW - anthrax

KW - antibiotics

KW - bacillus anthracis

KW - natural products

KW - polyketides

UR - https://www.scopus.com/pages/publications/84880338033

U2 - 10.1002/anie.201302749

DO - 10.1002/anie.201302749

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JF - Angewandte Chemie - International Edition

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ER -

Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete

Abstract

Keywords

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