Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete

Kyoung Hwa Jang, Sang Jip Nam, Jeffrey B. Locke, Christopher A. Kauffman, Deanna S. Beatty, Lauren A. Paul, William Fenical

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria.

Original languageEnglish
Pages (from-to)7822-7824
Number of pages3
JournalAngewandte Chemie - International Edition
Volume52
Issue number30
DOIs
StatePublished - 22 Jul 2013

Keywords

  • anthrax
  • antibiotics
  • bacillus anthracis
  • natural products
  • polyketides

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