Antartin, a cytotoxic zizaane-type Sesquiterpenoid from a Streptomyces sp. Isolated from an antarctic marine sediment

Dayoung Kim; Eun Ju Lee; Jihye Lee; Alain S. Leutou; Yern Hyerk Shin; Bomi Choi; Ji Sun Hwang; Dongyup Hahn; Hyukjae Choi; Jungwook Chin; Sung Jin Cho; Yong Deog Hong; Jaeyoung Ko; Chi Nam Seong; Katherine N. Maloney; Dong Chan Oh; Inho Yang; Hayoung Hwang; Sang Jip Nam

doi:10.3390/md16040130

Antartin, a cytotoxic zizaane-type Sesquiterpenoid from a Streptomyces sp. Isolated from an antarctic marine sediment

Dayoung Kim, Eun Ju Lee, Jihye Lee, Alain S. Leutou, Yern Hyerk Shin, Bomi Choi, Ji Sun Hwang, Dongyup Hahn, Hyukjae Choi, Jungwook Chin, Sung Jin Cho, Yong Deog Hong, Jaeyoung Ko, Chi Nam Seong, Katherine N. Maloney, Dong Chan Oh, Inho Yang, Hayoung Hwang, Sang Jip Nam

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.

Original language	English
Article number	130
Journal	Marine Drugs
Volume	16
Issue number	4
DOIs	https://doi.org/10.3390/md16040130
State	Published - Apr 2018

Bibliographical note

Publisher Copyright:
© 2018 by the authors.

Keywords

Cold water natural product
Marine natural product
Streptomyces sp.
Zizaane-type sesquiterpenoid

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10.3390/md16040130

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Kim, D., Lee, E. J., Lee, J., Leutou, A. S., Shin, Y. H., Choi, B., Hwang, J. S., Hahn, D., Choi, H., Chin, J., Cho, S. J., Hong, Y. D., Ko, J., Seong, C. N., Maloney, K. N., Oh, D. C., Yang, I., Hwang, H., & Nam, S. J. (2018). Antartin, a cytotoxic zizaane-type Sesquiterpenoid from a Streptomyces sp. Isolated from an antarctic marine sediment. Marine Drugs, 16(4), Article 130. https://doi.org/10.3390/md16040130

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title = "Antartin, a cytotoxic zizaane-type Sesquiterpenoid from a Streptomyces sp. Isolated from an antarctic marine sediment",

abstract = "Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.",

keywords = "Cold water natural product, Marine natural product, Streptomyces sp., Zizaane-type sesquiterpenoid",

author = "Dayoung Kim and Lee, {Eun Ju} and Jihye Lee and Leutou, {Alain S.} and Shin, {Yern Hyerk} and Bomi Choi and Hwang, {Ji Sun} and Dongyup Hahn and Hyukjae Choi and Jungwook Chin and Cho, {Sung Jin} and Hong, {Yong Deog} and Jaeyoung Ko and Seong, {Chi Nam} and Maloney, {Katherine N.} and Oh, {Dong Chan} and Inho Yang and Hayoung Hwang and Nam, {Sang Jip}",

note = "Publisher Copyright: {\textcopyright} 2018 by the authors.",

year = "2018",

month = apr,

doi = "10.3390/md16040130",

language = "English",

volume = "16",

journal = "Marine Drugs",

issn = "1660-3397",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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Kim, D, Lee, EJ, Lee, J, Leutou, AS, Shin, YH, Choi, B, Hwang, JS, Hahn, D, Choi, H, Chin, J, Cho, SJ, Hong, YD, Ko, J, Seong, CN, Maloney, KN, Oh, DC, Yang, I, Hwang, H & Nam, SJ 2018, 'Antartin, a cytotoxic zizaane-type Sesquiterpenoid from a Streptomyces sp. Isolated from an antarctic marine sediment', Marine Drugs, vol. 16, no. 4, 130. https://doi.org/10.3390/md16040130

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T1 - Antartin, a cytotoxic zizaane-type Sesquiterpenoid from a Streptomyces sp. Isolated from an antarctic marine sediment

AU - Kim, Dayoung

AU - Lee, Eun Ju

AU - Lee, Jihye

AU - Leutou, Alain S.

AU - Shin, Yern Hyerk

AU - Choi, Bomi

AU - Hwang, Ji Sun

AU - Hahn, Dongyup

AU - Choi, Hyukjae

AU - Chin, Jungwook

AU - Cho, Sung Jin

AU - Hong, Yong Deog

AU - Ko, Jaeyoung

AU - Seong, Chi Nam

AU - Maloney, Katherine N.

AU - Oh, Dong Chan

AU - Yang, Inho

AU - Hwang, Hayoung

AU - Nam, Sang Jip

PY - 2018/4

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AB - Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.

KW - Cold water natural product

KW - Marine natural product

KW - Streptomyces sp.

KW - Zizaane-type sesquiterpenoid

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DO - 10.3390/md16040130

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SN - 1660-3397

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JO - Marine Drugs

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ER -

Antartin, a cytotoxic zizaane-type Sesquiterpenoid from a Streptomyces sp. Isolated from an antarctic marine sediment

Abstract

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Keywords

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