@article{e581ca3c11574d17ac9d90d9e3a1f708,
title = "Antartin, a cytotoxic zizaane-type Sesquiterpenoid from a Streptomyces sp. Isolated from an antarctic marine sediment",
abstract = "Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.",
keywords = "Cold water natural product, Marine natural product, Streptomyces sp., Zizaane-type sesquiterpenoid",
author = "Dayoung Kim and Lee, {Eun Ju} and Jihye Lee and Leutou, {Alain S.} and Shin, {Yern Hyerk} and Bomi Choi and Hwang, {Ji Sun} and Dongyup Hahn and Hyukjae Choi and Jungwook Chin and Cho, {Sung Jin} and Hong, {Yong Deog} and Jaeyoung Ko and Seong, {Chi Nam} and Maloney, {Katherine N.} and Oh, {Dong Chan} and Inho Yang and Hayoung Hwang and Nam, {Sang Jip}",
note = "Funding Information: Acknowledgments: The present study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning under grant NRF-2017R1D1A1B03028172. Funding Information: The present study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning under grant NRF-2017R1D1A1B03028172. Publisher Copyright: {\textcopyright} 2018 by the authors.",
year = "2018",
month = apr,
doi = "10.3390/md16040130",
language = "English",
volume = "16",
journal = "Marine Drugs",
issn = "1660-3397",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",
}