Antartin, a cytotoxic zizaane-type Sesquiterpenoid from a Streptomyces sp. Isolated from an antarctic marine sediment

Dayoung Kim, Eun Ju Lee, Jihye Lee, Alain S. Leutou, Yern Hyerk Shin, Bomi Choi, Ji Sun Hwang, Dongyup Hahn, Hyukjae Choi, Jungwook Chin, Sung Jin Cho, Yong Deog Hong, Jaeyoung Ko, Chi Nam Seong, Katherine N. Maloney, Dong Chan Oh, Inho Yang, Hayoung Hwang, Sang Jip Nam

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18 Scopus citations

Abstract

Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.

Original languageEnglish
Article number130
JournalMarine Drugs
Volume16
Issue number4
DOIs
StatePublished - Apr 2018

Bibliographical note

Publisher Copyright:
© 2018 by the authors.

Keywords

  • Cold water natural product
  • Marine natural product
  • Streptomyces sp.
  • Zizaane-type sesquiterpenoid

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