Antaroide, a novel natural nine-membered macrolide, inhibits melanin biosynthesis in b16f10 murine melanoma cells

Min Ji Ryu, Eun Ki Baek, Soyeon Kim, Chi Nam Seong, Inho Yang, Kyung Min Lim, Sang Jip Nam

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Inten-sive investigation on the culture broth of Streptomyces sp. SCO-736, a marine bacterium from the Antarctica coast, has led to the isolation of a new natural product named antaroide (1). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the α-melanocyte stimulating hormone (α-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents.

Original languageEnglish
Pages (from-to)98-103
Number of pages6
JournalBiomolecules and Therapeutics
Volume29
Issue number1
DOIs
StatePublished - 2021

Keywords

  • Marine natural product
  • Melanin synthesis inhibitor
  • Nine-membered macrolide
  • Skin whitening agent
  • Streptomyces sp

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