The demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Inten-sive investigation on the culture broth of Streptomyces sp. SCO-736, a marine bacterium from the Antarctica coast, has led to the isolation of a new natural product named antaroide (1). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the α-melanocyte stimulating hormone (α-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents.
Bibliographical noteFunding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science and ICT under Grant No. NRF-2019R1F1A1059033 (to Yang I), 2018R1A5A2025286 (to Lim KM), 2017R1D1A1B03028172 (to Nam SJ).
© 2021 The Korean Society of Applied Pharmacology.
- Marine natural product
- Melanin synthesis inhibitor
- Nine-membered macrolide
- Skin whitening agent
- Streptomyces sp