Antaroide, a novel natural nine-membered macrolide, inhibits melanin biosynthesis in b16f10 murine melanoma cells

Min Ji Ryu, Eun Ki Baek, Soyeon Kim, Chi Nam Seong, Inho Yang, Kyung Min Lim, Sang Jip Nam

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7 Scopus citations


The demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Inten-sive investigation on the culture broth of Streptomyces sp. SCO-736, a marine bacterium from the Antarctica coast, has led to the isolation of a new natural product named antaroide (1). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the α-melanocyte stimulating hormone (α-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents.

Original languageEnglish
Pages (from-to)98-103
Number of pages6
JournalBiomolecules and Therapeutics
Issue number1
StatePublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 The Korean Society of Applied Pharmacology.


  • Marine natural product
  • Melanin synthesis inhibitor
  • Nine-membered macrolide
  • Skin whitening agent
  • Streptomyces sp


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